ESPEYB15 1 Pituitary and Neuroendocrinology New mechanisms (6 abstracts)
1.5 NOTCH activity differentially affects alternative cell fate acquisition and maintenance
Cheung L , Le Tissier P , Goldsmith SG , Treier M , Lovell-Badge R & Rizzoti K
Centre for Discovery Brain Science, Integrative Physiology, Edinburgh, United Kingdom.
The Francis Crick Institute, London, United Kingdom
To read the full abstract: Elife 2018;7. pii: e33318
Here, Cheung et al. use sophisticated tissue specific genetic ablation in pituitary cell lineages to uncover an unexpected differential sensitivity of NOTCH activation signalling pathway in different cell lineages during the embryonic murine pituitary development. These findings are important as they further demonstrate the importance of NOTCH pathway in progenitor differentiation during pituitary development and consequently reveals new aspects of endocrine lineages and plasticity. Further work on the molecular differences on cell specific lineages and cell fate acquisition will be important to fine tune the mechanisms that generate pituitary plasticity. Importantly it will be useful to understand if these mechanisms are maintained in adult pituitary stem cells upon endocrine challenges to maintain adult organ homeostasis.
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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