Adipose tissue – a main source of miRNAs | 0015 | ESPEYB15 | Yearbook of Paediatric Endocrinology 2018 | ESPE Yearbook of Paediatric Endocrinology

ey0015.11-13 | Adipose tissue – a main source of miRNAs | ESPEYB15

11.13 Adipose-derived circulating miRNAs regulate gene expression in other tissues

T Thomou , M Mori , J Dreyfuss , M Konishi , M Sakaguchi , C Wolfrum , T Nageswara Raa , J Winnay , R Garcia-Martin , S Grinspoon , P Gorden , R Kahn

To read the full abstract: Nature 2017, 542, 450–455Adipose tissue is no longer considered a passive energy store. Instead, it is well established as an important endocrine contributor. Here, the authors comprehensively show that the function of the adipose tissue as an endocrine organ is not limited to classical adipokines, but also includes miRNAs and maybe other non-coding RNAs. This study...

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ey0015.11-14 | Adipose tissue – a main source of miRNAs | ESPEYB15

11.14 Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity

W Ying , M Riopel , G Bandyopadhyay , Y Dong , A Birmingham , J Bae Seo , J Ofrecio , J Wollam , A Hernandez-Carretero , W Fu , P Li , J Olefsky

To read the full abstract: Cell 2017, Volume 171, Issue 2Here, the group of Jerrold Olefsky identified adipose tissue macrophages as important sources of microRNAs regulating metabolic processes not only within the adipose tissue depot, but also in an endocrine way in other distant tissues. The application of exosomes derived from ATMs isolated from obese mice caused insulin resistance both ...

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ESPE Yearbook of Paediatric Endocrinology

Yearbook of Paediatric Endocrinology 2018

11 Obesity and Weight Regulation

Adipose tissue – a main source of miRNAs

11.13 Adipose-derived circulating miRNAs regulate gene expression in other tissues

11.14 Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity

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