ESPEYB15 10 Type 1 Diabetes Mellitus Comorbidities – short and long-term complications (5 abstracts)
10.13 Prevalence of celiac disease in 52,721 youth with T1DM: international comparison across three continents
Craig ME , Prinz N , Boyle CT , Campbell FM , Jones TW , Hofer SE , Simmons JH , Holman N , Tham E , Fröhlich-Reiterer E , DuBose S , Thornton H , King B , Maahs DM , Holl RW & Warner JT
Australasian Diabetes Data Network (ADDN); T1D Exchange Clinic Network (T1DX); National Paediatric Diabetes Audit (NPDA) and the Royal College of Paediatrics and Child Health; Prospective Diabetes Follow-up Registry (DPV) initiative.
The Children’s Hospital at Westmead, Sydney, New South Wales, Australia
To read the full abstract: Diabetes Care. 2017;40:1034-1040
Researchers from The Children’s Hospital at Westmead, Sydney, Australia as well as scientists from institutions from three different continents, America, Europe and Australia have combined their data from large diabetes registries in order to: examine the prevalence of celiac disease (CD) in populations of patients with T1DM; investigate international differences in the prevalence of CD; and characterize the clinical characteristics of youth with coexisting T1DM and CD versus T1DM only.
CD is common in patients with T1DM and the differences of prevalence might reflect differences in screening strategies and differences in medical services in different countries and cultural differences between continents, rather than true differences in prevalence of CD. The clinical course of T1DM did not differ between patients with CD or those without. However, patients with T1DM and CD were shorter than patients with T1DM only. It is well known that untreated CD may cause growth failure and short stature. It might be hypothesized that some patients with T1DM and CD in these cohorts had CD diagnosed too late to prevent growth impairment or even growth failure. Screening for CD should therefore be advocated and carried out meticulously. In addition, close monitoring of growth, weight and pubertal development in pediatric and adolescent populations is mandatory. This is even more so in populations with chronic diseases such as T1DM.
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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