ESPEYB15 10 Type 1 Diabetes Mellitus Aetiology and heterogeneity of type 1 diabetes (3 abstracts)
10.2 Higher parental occupational social contact is associated with a reduced risk of incident pediatric T1DM: mediation through molecular enteroviral indices
Ponsonby AL , Pezic A , Cameron FJ , Rodda C , Kemp AS , Carlin JB , Hyoty H , Sioofy-Khojine A , Dwyer T , Ellis JA & Craig ME
Murdoch Children’s Research Institute, Royal Children’s Hospital, University of Melbourne, Flemington Rd, Parkville, Victoria, Australia
To read the full abstract: PLoS One. 2018;13:e0193992
Enterovirus infections in children are associated with an almost 10-fold higher risk of T1DM. In these families in parents and siblings enterovirus can frequently be detected by PCR. However, the role of enteroviral infections in the pathogenesis of T1DM is complex. Although enterovirus infections are less prevalent T1DM incidence increases. Herd immunity could be an explanation in this constellation. High social contact occupations are associated with a greater infection rate. This may reboost established immune responses against pathogens. Beneath the effect of occupational contacts, hand hygiene of the children was analyzed in this study. Higher parental occupational social contact is strongly associated with a reduced T1D risk in children with a strong dose response. In part this can be explained by antibodies in mothers of newborn children that had contact with enterovirus before pregnancy. On the other hand, children’s better hand hygiene protects against T1D risk.
Combination of both protective factors is associated with an almost 10-fold T1D risk reduction. So hand hygiene to prevent children`s enteroviral infection plays an important role in protecting against beta cell autoimmunity.
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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