ESPEYB15 10 Type 1 Diabetes Mellitus Aetiology and heterogeneity of type 1 diabetes (3 abstracts)
10.3 Frequency and phenotype of T1DM in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank
Thomas NJ , Jones SE , Weedon MN , Shields BM , Oram RA & Hattersley AT
Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK
To read the full abstract: Lancet Diabetes Endocrinol. 2018;6:122-129
T1DM formerly called juvenile or insulin dependent diabetes has so far been considered to be a disease of children adolescents and young adults according to traditional teaching. LADA or late autoimmune diabetes of the adult is known since several decades, however the older the patient with new onset diabetes the more likely he will be diagnosed as Type 2 diabetes because of the high background Type 2 prevalence. There is not much data available on the frequency of T1DM in adults older than 30 years. As one would assume those adults (31-60 years) with T1DM onset are more likely to have a normal or slightly elevated BMI, need often insulin within the first year of diagnosis and present more frequently with DKA. For appropriate treatment with insulin, diabetologists should keep in mind that slim patients in middle age could have T1DM. Especially parents of children in our treatment with new onset diabetes should be indicated that they could develop T1DM.
Volume 15
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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