ESPEYB15 14 Science and Medicine Gut flora is shaped by the environment (1 abstracts)
14.5 Environment dominates over host genetics in shaping human gut microbiota
Rothschild D , Weissbrod O , Barkan E , Kurilshikov A , Korem T , Zeevi D , Costea PI , Godneva A , Kalka IN & Bar N
To read the full abstract: Nature 2018;555:210
Up to now, it was thought that genetics would play a major role in shaping the gut flora. However, this study, in a cohort of 1,046 healthy Israeli individuals with a well-defined clinical phenotype, suggests that only 2-8% of human microbiome variability is explained by genetics, as compared to 92-98% explained by environmental influences. This study shows that the microbiome is not significantly associated with genetic ancestry or with individual SNPs. There was significant similarity among the microbiomes of genetically unrelated individuals who share a household, but no such similarity among relatives without a history of household sharing. The gut’s microbiome is mostly influenced by lifestyles; our diets, physical activity and mediation history. It was recently reported that the microbiome has an important impact on immune responses, and it seems that this may be a new route whereby lifestyles may influence immune and other health outcomes. An obvious yet unknown question arising from such observations is whether manipulating the microbiome could influence later health and disease.
Volume 15
Article tools
My recent searches
My recently viewed abstracts
Authors
ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more