ESPE Yearbook of Paediatric Endocrinology

To read the full report: https://www.fda.gov/NewsEvents

The report, issued by the U.S. National Toxicological Program (NTP), presents the initial results of a multimillion dollar study conducted for more than 5 years by scientists at FDA’s National Center for Toxicological Research. It looked at the effects of different doses of BPA evaluating chronic and early life exposure in two different groups of rodents. In the chronic part, laboratory animals were exposed to BPA from pregnancy, through early-life development, and continuing through their entire lifetime. The doses ranged from low doses, that would be comparable to typical human exposures, to doses that vastly exceed human exposures. A variety of endpoints were evaluated. The study confirms the absence of health effects at typical human exposure levels. The actual article is yet to be published, so this report precedes usual peer review, so that other than the conclusions, we haven’t seen yet the methods or the results. The Endocrine Society expressed concern with this statement, saying that “It is premature to draw conclusions based on the release of one component of a two-part report. Policymakers and regulators should reserve judgment until the full report is released”, which will include data on additional endpoints. https://www.endocrine.org/news-room/2018/endocrine-society-experts-express-concern-with-fda-statement-on-bpa-safety