ESPEYB15 5 Bone, Growth Plate and Mineral Metabolism Of poodles and danes (1 abstracts)
5.14 Growth plate expression profiling: Large and small breed dogs provide new insights in endochondral bone formation
Teunissen M , Riemers FM , van Leenen D , Groot Koerkamp MJA , Meij BP , Alblas J , Penning LC , Miranda-Bedate A & Tryfonidou MA
Faculty of Veterinary Medicine, Department of Clinical Sciences of Companion Animals, Utrecht University, Utrecht, The Netherlands
To read the full abstract: J Orthop Res 2018;36:138-148
Dogs are growth biologists’ best friends – due to the broad intra-species variance in body size, canine breeds offer a unique opportunity to study genetic differences mainly affecting linear growth. In their previous publication, the authors found drastic differences between miniature and large dog breeds in known key regulators of the growth plate such as IHH, PTHrP, and IGF-BPs (1). In the present study, the group took the concept to a next level and extended the study approach by using Microarray technology. Further, the authors addressed the essential issue of spatial expression in growth plate tissue by validating array-derived data in individual growth plate zone samples. This two-level approach allowed identification of new body-size related differences including BMP2 and BMP6 expression in proliferative chondrocytes and osseous expression of BMPR1b.
While some new regulators might still have remained under the radar due to the use of total growth plate sample for Microarray analysis, the identification of known chondrocyte differentiation regulators validated this compelling study design. Follow-up studies with focus on further regulatory pathways are hoped for.
1. Tryfonidou MA, Hazewinkel HA, Riemers FM, Brinkhof B, Penning LC, Karperien M. Intraspecies disparity in growth rate is associated with differences in expression of local growth plate regulators. Am J Physiol Endocrinol Metab. 2010 Dec;299(6):E1044-52.
Volume 15
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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