ESPEYB15 5 Bone, Growth Plate and Mineral Metabolism Fractures, vitamin D and steroids – unclear associations (2 abstracts)
5.7 Vitamin D and Fracture Risk in Early Childhood: A Case-Control Study
Anderson LN , Heong SW , Chen Y , Thorpe KE , Adeli K , Howard A , Sochett E , Birken CS , Parkin PC & Maguire JL; TARGet Kids Collaboration
Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
Child Health Evaluative Sciences Program, The Hospital for Sick Children, Toronto, Ontario, Canada
To read the full abstract: Am J Epidemiol 2017;185:1255-1262
Vitamin D and adequate dietary calcium intake are important for skeletal health and therefore it was expected that vitamin D concentration would be associated with increased fracture risk. However, here, the authors did not find any statistically significant association between concurrent 25(OH)D concentration and fracture risk. In addition, the main dietary source of vitamin D in Canada, milk intake, was also not statistically significantly associated with reduced risk of fractures.
Previous studies have reported a high prevalence of 25(OH)D deficiency (<50 nmol/L), among children with fractures (1); however, none of those studies included a comparison group of children without fractures. In this study, controls were obtained from the TARGet Kids! primary-care research network and were matched to cases on age, sex, height, and season. Another strength of this study was that fractures were confirmed by radiography. One of the limitations of this study is that 25(OH)D levels in the study population were sufficiently high to have minimized fracture risk from vitamin D insufficiency, and results from this study therefore may not be generalizable to other populations with lower 25(OH)D levels.
1. Clark EM. The epidemiology of fractures in otherwise healthy children. Curr Osteoporos Rep. 2014;12(3):272–278.
Volume 15
Article tools
My recent searches
My recently viewed abstracts
Authors
ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more