ESPEYB15 8 Adrenals New Mechanisms (3 abstracts)
8.5 Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla
Furlan A , Dyachuk V , Kastriti ME , Calvo-Enrique L , Abdo H , Hadjab S , Chontorotzea T , Akkuratova N , Usoskin D , Kamenev D , Petersen J , Sunadome K , Memic F , Marklund U , Fried K , Topilko P , Lallemend F , Kharchenko PV , Ernfors P & Adameyko I
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
To read the full abstract: Science. 2017; 357(6346)
Current textbooks teach that adrenergic chromaffin cells of the adrenal medulla originate from a sympathoadrenal cell lineage of the neural crest nearby the dorsal aorta. Here, Furlan et al. demonstrate a novel origin of these neuroendocrine cells of the medulla arising predominantly from Schwamm cell precursors (SCP) of peripheral nerves. Previously it had been shown that SCPs serve as multipotent stem cells that can differentiate into various cell types, most importantly parasympathetic nerve cells. Using genetic cell fate tracing, SCP and nerve ablation, as well as chromaffin differentiation interference studies in mice, the authors show that most chromaffin cells of the adrenal medulla originated from SCP. They describe lineage segregation of chromaffin cells from sympathoblasts, and the specific gene program driving SCP into chromaffin cells via a defined bridge transition phase. Overall, the adrenal medulla seems to be formed in two steps. Organogenesis step one consists of expansion of the SCPs; step two, proliferation of the chromaffin cells. Peripheral nerves provide niches for progenitor cells and avenues for cell migration also important for neuroendocrine organ development. This new finding may have implications on the understanding of neuroblastoma and pheochromocytoma, which both mostly arise from the adrenal gland region.
Volume 15
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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