ESPEYB15 9 Oncology and chronic disease Late consequences of tumour therapy: prevention and monitoring (3 abstracts)
9.1 Late outcomes of adult survivors of childhood non-Hodgkin lymphoma: A report from the St. Jude Lifetime Cohort Study
Ehrhardt MJ , Sandlund JT , Zhang N , Liu W , Ness KK , Bhakta N , Chemaitilly W , Krull KR , Brinkman TM , Crom DB , Kun L , Kaste SC , Armstrong GT , Green DM , Srivastava K , Robison LL , Hudson MM & Mulrooney DA
Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN, USA
To read the full abstract: Pediatr Blood Cancer. 2017;64(6):e26338
Through a comprehensive, risk-based clinical assessment and validation of medical events, this study provides a detailed heath status characterization of adult survivors of paediatric non-Hodgkin lymphoma (NHL). Survivors showed an increased risk of suffering from one or more components of the metabolic syndrome (obesity 35%, hypertension 9%, elevated fasting glucose 2.5%, and high cholesterol 1%), well known cardiovascular risk factors. Many survivors experienced physical performance limitations and a mild or severe neurocognitive impairment was detected in more than two-thirds of them. As the authors point out, the evaluation of physical performances appears of interest because the early identification of functional limitations may enhance the ability to reduce modifiable cardiovascular risk factors in these patients. Possible limitations of this study were the selection bias (participants were more likely to be female, younger, and fewer years from NHL). Treatment protocols are now different from those used decades ago in both intensity and omission of irradiation, thus it appears difficult to generalize the conclusions to recent NHL survivors. While the high prevalence of cardiovascular risk factors represents a well-known complication in hematologic cancer survivors, the most relevant merit of this study was to point the attention on limitations of neurocognitive performance and physical function. Early recognition of these conditions offers an opportunity to improve the quality of life of these patients.
Volume 15
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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