ESPEYB15 9 Oncology and chronic disease Bone health monitoring in chronic disease: broaden existing knowledge (1 abstracts)
9.14 Structural basis of bone fragility in young subjects with inflammatory bowel disease: a high-resolution pQCT study of the SWISS IBD Cohort (SIBDC)
Pepe J , Zawadynski S , Herrmann FR , Juillerat P , Michetti P , Ferrari-Lacraz S , Belli D , Ratib O , Rizzoli R , Chevalley T & Ferrari SL
Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
To read the full abstract: Inflamm Bowel Dis. 2017;23:1410-1417
This cross-sectional study analyzed bone health status by high-resolution peripheral quantitative computed tomography (HRpQTC) of a Swiss Cohort of young patients with inflammatory bowel disease (IBD) in comparison to healthy controls, matched for sex, age, height and fracture history. The results showed subtle abnormalities in bone microarchitecture that were not evident on dual-energy x-ray absorptiometry (DXA). These abnormalities seemed to be directly correlated with the disease and the fracture risk, considering the significant differences in comparison to controls. These data suggest that HR-pQTC might become the gold standard technique to identify modifications of bone architecture, despite its higher costs. The lower exposure to radiation of HR-pQTC, compared to DXA, is an additional benefit. It is noteworthy that this study analysed data of patients with mean age at diagnosis 17.3 years; this suggests the need to validate the results also in patients with childhood-onset IBD. More attention should be given to growth measures and pubertal staging, while in this study puberty was evaluated only by a self-assessment questionnaire (as several other clinical variables) and anthropometric parameters were not converted into Z-scores.
Volume 15
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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