ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2019

ey0016.4-12 | New Paradigms | ESPEYB16

4.12. Expression of insulin-like growth factor I and its receptor in the liver of children with biopsy-proven NAFLD

A Alisi , V Pampanini , C De Stefanis , N Panera , A Deodati , V Nobili , S Cianfarani

To read the full abstract: PLoS One. 2018;13:e0201566.NAFLD is a multifactorial disease characterized by an abnormal accumulation of fat in the liver without a history of significant alcohol intake. NAFLD is the most common form of chronic liver disease, affecting 30% of adults and 10% of children in the USA [1]. Alarmingly, its prevalence is increasing worldwide paralleling to the incre...

ey0016.4-13 | New Paradigms | ESPEYB16

4.13. Growth hormone-Insulin-like growth factor 1 axis hyperactivity on bone fibrous dysplasia in McCune-Albright Syndrome

D Tessaris , AM Boyce , M Zacharin , P Matarazzo , R Lala , L De Sanctis , MT Collins

To read the full abstract: Clin Endocrinol. 2018;89:56–64.McCune Albright syndrome (MAS) is a rare disorder caused by somatic gain-of-function mutations of the GNAS gene [1]. This gene encodes the α-subunit of the Gs protein and its mutations are responsible for persistent stimulation of adenylyl cyclase and dysregulated production of cyclic AMP leading to persistent o...