ESPEYB17 3. Thyroid Clinical trials for thyroid disease (3 abstracts)
3.13. Cognitive function in children with idiopathic subclinical hypothyroidism: Effects of 2 years of levothyroxine therapy
Capalbo D , Alfano S , Polizzi M , Di Mase R , Improda N , Esposito A , Bravaccio C & Salerno M
To read the full abstract: J Clin Endocrinol Metab. 2020;105:e774–e7781.
This prospective non-randomized clinical trial investigated the effect of two-years levothyroxine treatment in children with subclinical hypothyroidism (TSH 5.0–9.9 mU/l with normal FT4 for two years preceding the study) starting at a mean age of 9 years. Capalbo et al. observed no change in IQ scores in 20 children after two-years of levothyroxine. Further, they observed no differences in IQ between these 20 treated and a further 14 untreated patients after two years.
The consequences of mild subclinical hypothyroidism on cognitive function during childhood is debated. In analogy to adults, levothyroxine treatment in children with subclinical hypothyroidism and a TSH <10 mU/l without clinical signs or symptoms is controversial. These important data, although limited by a small sample size and lack of randomization, showed no benefit of levothyroxine on IQ and all relevant subclasses in childhood over the so far longest observation period. Whether more complex and specific cognitive testing would reveal significant effects remains open. In summary, current practice of non-treatment of asymptomatic patients with a TSH below 10 is strengthened.
Volume 17
Article tools
My recent searches
My recently viewed abstracts
Authors
ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more