ESPEYB17 9. Oncology and Chronic Disease Premature Aging, Cardiometabolic Fitness and Cardiovascular Damage (3 abstracts)
9.11. Retinal vessel analysis as a novel screening tool to identify childhood acute lymphoblastic leukemia survivors at risk of cardiovascular disease
Azanan MS , Chandrasekaran S , Rosli ES , Chua LL , Oh L , Chin TF , Yap TY , Rajagopal R , Rajasuriar R , MacGillivray T , Trucco E , Ramli N , Kamalden TA & Ariffin H
To read the full abstract: J Pediatr Hematol Oncol. 2020;10.1097/MPH.0000000000001766. doi:10.1097/MPH.0000000000001766 [published online ahead of print, 2020 Feb 28]. taftkamalden@um.edu.my
Childhood cancer survivors (CCS) have a markedly increased incidence of early cardiovascular disease (CVD). Changes in retinal vessel diameter are associated with CVD risk and stroke mortality. This cross-sectional study analysed retinal microvasculature, arterial stiffness, endothelial activation markers and cardiovascular risk factors in 73 young survivors of childhood acute lymphoblastic leukaemia (cALL) and 78 healthy controls. The purpose of the study was to investigate whether retinal vessel analysis can represent a feasible method to assess endothelial health in survivors of cALL. Retinal fundus images were summarized into two different retinal vessel measurements: central retinal artery/vein equivalents (CRAE/CRVE) and arteriolar-venular ratio (AVR).
In comparison with age-matched controls, cALL survivors had higher cardiovascular risk factors and more retinal signs of microvascular damage (higher CRVE, lower AVR). Their arterial stiffness and endothelial activation markers (sVCAM-1) were also increased. The authors suggest that retinal vessel changes could predate overt clinical abnormalities such as obesity or metabolic abnormalities. Indeed, 10 survivors demonstrated arterial changes despite having normal triglyceride levels and BMI (although it is well known that BMI underestimates the proportion of fat tissue in cancer survivors). The potential clinical application of retinal vessel analysis, as a noninvasive early screening tool for identifying survivors at increased risk for CVD, is clearly interesting. The cross-sectional design of this study represents a clear limitation, since only serial assessments could clarify to what extent the severity of retinal microvascular changes can predict the development of cardiovascular morbidities.
Reference:
1. Blijdorp K, van den Heuvel-Eibrink MM, Pieters R, et al. Obesity is underestimated using body mass index and waist-hip ratio in long-term adult survivors of childhood cancer. PLoS One. 2012;7:e43269.
Volume 17
Article tools
My recent searches
My recently viewed abstracts
Authors
ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more