ESPEYB19 12. Type 2 Diabetes, Metabolic Syndrome and Lipids Metabolic syndrome (5 abstracts)
12.10. Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis
Sato S , Dyar KA , Treebak JT , Jepsen SL , Ehrlich AM , Ashcroft SP , Trost K , Kunzke T , Prade VM , Small L , Basse AL , Schönke M , Chen S , Samad M , Baldi P , Barrès R , Walch A , Moritz T , Holst JJ , Lutter D , Zierath JR & Sassone-Corsi P.
Cell metabolism 2022;34(2):329-45.e8. doi: 10.1016/j.cmet.2021.12.016
Brief Summary: In a mouse model, time of exercise during the day was found to determine the magnitude and type of metabolic response. Different tissues responded to exercise at different times of the day.
Comment: Exercise is considered a vital intervention in the prevention and treatment of individuals with chronic and metabolic diseases. However, a growing body of evidence shows that exercise has different results at different times of the day, among different populations. Furthermore, the optimal timing of exercise depends on whether the aim is to improve muscle strength, improve glycemic control, reduce weight loss or reduce depression.
Circadian clocks orchestrate biological processes, including hormone production, behavior and metabolism. Disruption of the circadian clock causes metabolic diseases. While the light/dark cycle has a powerful effect on the circadian clock, feeding and exercise have been shown to reset the circadian clock.
To better understand outcomes of exercise at different times of the day, healthy male mice performed 1-h treadmill exercise either in the early light/rest phase (0900 h) or in the early dark/active phase (2100 h), and were compared to mice who were resting during these times. To understand the exercise-dependent signaling, biochemicals, serum, skeletal muscle, liver, heart, hypothalamus and adipose tissue were collected, and metabolites assessed. Of note, mice are nocturnal. A number of important insights were found:• Different tissues respond to exercise at different times of the day. For example, exercise at night altered 197 muscle metabolites, whereas daytime exercise impacted only 52 metabolites.• Responses of different tissues connect and induce an orchestrated adaptation to control systemic energy homeostasis.• Morning workouts tended to signal greater reliance on fat than sugars to fuel early exercise.• Late-day workouts might be better for blood-sugar control.
A limitation of the study is it mainly examined a single session of moderate aerobic exercise in male mice. Nonetheless, the notion that exercise has different impact at different times of day and that we can time workouts to achieve specific health goals is intriguing.
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ESPE Yearbook of Paediatric Endocrinology
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