ISSN 1662-4009 (online)

ESPE Yearbook of Paediatric Endocrinology (2022) 19 7 | DOI: 10.1530/ey.19.7
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1Department of Pediatrics, University Hospital Liège, Belgium; 2Neuroendocrinology Unit, GIGA-Neurosciences, University of Liège, Belgium; 3Specialty School of Paediatrics – Alma Mater Studiorum, University of Bologna, Italy


Introduction: This year brought us some fascinating data regarding extra-hypothalamic GnRH neurons as well as a new player in puberty and growth regulation, MC3R. It also highlighted the crucial role of glial cells and tanycytes in the developmental processes leading to puberty. From a clinical point of view, this year’s studies opened new avenues for better discriminating between self-limiting delayed puberty and isolated hypogonadotropic hypogonadism.

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