ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Lancet Child Adolesc Health. 2019 Jan;3(1):44–54.This article reviews cross-sectional, longitudinal and intervention studies regarding the bidirectional relationship between obesity and puberty.An increasing prevalence of obesity amongst children and adolescents is reported globally. Epidemiological cross-sectional and...

To read the full abstract: Growth Hormone & IGF Research 2020; 50: 48–56. doi: 10.1016/j.ghir.2019.11.004• The authors summarize the historical aspects of the discovery of mechanisms underlying short and tall stature in South America.• Tall stature stories include gigantism in Patagonia, acromegaly and the relationship between glucose metabolism and GH excess.• S...

To read the full abstract: Pregnancy Hypertens. 2019 Jan;15:134–140.This observational cohort study highlights the negative association between age at menarche and blood pressure in pregnancy, and the probable relationship with BMI and insulin resistance.Age at menarche (AAM) is influenced by genetic and environmental determinants (1). Given that some...

Int J Obes (Lond). 2020 Oct;44(10):2011–2022. 10.1038/s41366-020-0644-1. https://pubmed.ncbi.nlm.nih.gov/32713944/Schur et al. addressed the question, whether responsiveness to visual food cues in functional magnetic resonance imaging (fMRI) is related to the treatment success of a 6-month Family-based Behavioral Treatment (...

Christian.roth@deattlechildrens.org J Clin Endocrinol Metab. 2022; doi: 10.1210/clinem/dgac299. https://pubmed.ncbi.nlm.nih.gov/35544121/Brief Summary: In this intervention study, the effect of a 24-week family-based behavioral obesity intervention on brain activation, measured by v...

To read the full abstract: The FASEB Journal 2019;33:12680–12695.These authors conditionally deleted the IGF1 receptor gene (IGF1R) in tenocytes using a tamoxifen-inducible Cre-recombinase system and then stimulated plantaris tendon growth in adult mice via mechanical loading. Mice that lacked IGF1R in their tenocytes showed reduced cell proliferation and tendon growth in response to mechanical loading. These studies indicate that IGF1 sign...

To read the full abstract: Lancet Diabetes Endocrinol 2018; 6:69-80The prevalence of T2DM in youth is increasing dramatically worldwide, but the bulk of the increase is expected to take place in Africa, South East Asia and South America. Although genetic factors may seem to be the obvious reason for such geographical differences, a careful analysis of the existing literature suggests that...

Brief summary: Roth et al. studied the relationship between obesity outcomes and meal-induced changes in neural activation to high- versus low-calorie food cues before and after 24-week family-based behavioral treatment (FBT) in n=28 children (9–11 years) with obesity and in n=17 children of healthy weight without intervention (9–11 years). Among children with obesity who underwent FBT, unfavorable changes were observed in peripheral hormon...

Brief summary: This 12-months randomized, controlled, phase 3 study compared the efficacy and safety of once-weekly Somatrogon 0.66 mg/kg/week with once-daily somatropin in prepubertal children with GHD. The efficacy of once-weekly Somatrogon was noninferior to once-daily somatropin, with similar safety and tolerability profiles.Somatrogon (MOD-4023) is a long-acting rhGH recently approved by the European Medicines Agency for the treatment of children wi...

Eur J Endocrinol. 2020;183:637–645. doi: 10.1530/EJE-20-0617.This study provides for the first time clear evidence that the block and replace (BR) strategy (combination of carbimazole plus levothyroxine) is not superior to the carbimazole dose titration (DT) strategy for treatment of paediatric Graves’ disease.Wood et al. present the first randomized c...