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ey0015.2-18 | Dietary composition, age, and sex determine the central inflammatory response associated with the long-term outcomes of excess weight gain | ESPEYB15

Dietary composition, age, and sex determine the central inflammatory response associated with the long-term outcomes of excess weight gain

P Argente-Arizón , F Díaz , P Ros , V Barrios , M Tena-Sempere , LM García-Segura , J Argente , JA Chowen

To read the full abstract: Endocrinology. 2018 Jan 1;159(1):368-387Hypothalamic inflammation has been linked to the development and progression of obesity and its sequelae. Obesity in rodents and humans is associated with gliosis of the arcuate nucleus, a key hypothalamic region for the regulation of energy homeostasis and adiposity. Gliosis, the activation of astrocyte and microglial cell popula...

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ey0015.15-17 | Neanderthal's’ child growth | ESPEYB15

15.17 The growth pattern of Neandertals, reconstructed from a juvenile skeleton from El Sidrón (Spain)

A Rosas , L Ríos , A Estalrrich , H Liversidge , A García-Tabernero , R Huguet , H Cardoso , M Bastir , C Lalueza-Fox , M de la Rasilla

To read the full abstract: Science 2017;357:1282-1287This Neanderthal boy died 49,000 years ago from an unknown cause at a dental age of 7.7 years. Most of his bones agreed with this estimation. The authors claim that his general pattern of growth was like that of modern humans, except that the atlas and mid-thoracic vertebrae matured later and remained at the 5-6-year stage of deve...

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ey0015.2-1 | A novel disorder of hyperinsulinaemic hypoglycaemia and polycystic kidneys | ESPEYB15

A novel disorder of hyperinsulinaemic hypoglycaemia and polycystic kidneys

OR Cabezas , SE Flanagan , H Stanescu , E García-Martínez , R Caswell , H Lango-Allen , M Antón-Gamero , J Argente , AM Bussell , A Brandli , C Cheshire , E Crowne , S Dumitriu , R Drynda , JP Hamilton-Shield , W Hayes , A Hofherr , D Iancu , N Issler , C Jefferies , P Jones , M Johnson , A Kesselheim , E Klootwijk , M Koettgen , W Lewis , JM Martos , M Mozere , J Norman , V Patel , A Parrish , C Pérez-Cerdá , J Pozo , SA Rahman , N Sebire , M Tekman , PD Turnpenny , WV Hoff , DHHM Viering , MN Weedon , P Wilson , L Guay-Woodford , R Kleta , K Hussain , S Ellard , D Bockenhauer

To read the full abstract: J Am Soc Nephrol. 2017 Aug;28(8):2529-2539The association of hyperinsulinaemic hypoglycaemia (HH) and polycystic kidneys has not been reported before. Here, the authors studied 17 patients from 11 different families and found that all patients had a combination HH and polycystic kidneys. The HH was mild and some patients required diazoxide therapy. In contrast the poly...

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ESPE Yearbook of Paediatric Endocrinology

Dietary composition, age, and sex determine the central inflammatory response associated with the long-term outcomes of excess weight gain

15.17 The growth pattern of Neandertals, reconstructed from a juvenile skeleton from El Sidrón (Spain)

A novel disorder of hyperinsulinaemic hypoglycaemia and polycystic kidneys

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