ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Science Advances 2018;4:eaao5961Present-day humans have globular brains and globular endocasts with steep frontal, bulging parietal, and enlarged, rounded cerebellar areas with small and retracted faces. In contrast, Neandertals and other archaic Homo individuals have anterior-posteriorly elongated flat endocasts. These differences are well-visualized...

J Pediatr Urol. 2018 Oct;14(5):416.e1–416.e5.doi: 10.1016/j.jpurol.2018.04.029. PubMed ID: 29903608This paper discusses the management of three DSD cases with difficult sex assignment at a US center. The goal of this report was to explore factors involved in parental decision making and the challenge to reconcile respect for the child’s integrity with ...

Thyroid. 2020;30:1831–1833. doi: 10.1089/thy.2020.0293.Every year, we report on new genes that have been associated with congenital hypothyroidism. But it is the first time in all these years that, following the first description, other groups from different continents confirm the first reports in independent cohorts in such a short time after publication.This is ...

Nat Commun. 2020;11:4807. doi: 10.1038/s41467-020-18497-3.This interesting paper illustrates the potential of machine learning to improve the sensitivity and specificity of routine techniques in clinical practice if large cohorts for training and validation of models are used. Yu et al. present a transfer learning model (machine learning approach to solve research problems by r...

Diabetes Care. 2022 Apr 1;45(4):871-879. https://pubmed.ncbi.nlm.nih.gov/35147706/Brief Summary: This Finnish cross-sectional register-based study of 6015 youth with new onset type 1 diabetes (T1D) explored potential differences in clinical, autoimmune and genetic characteristics across three age groups: <7, 7-12 and ≥13 years. Significant differences emerged primarily between the...

To read the full abstract: Cochrane Database Syst Rev. 2019;2019(11). doi: 10.1002/14651858.CD006401.pub5Short summary: This systematic review shows that statin treatment is an effective lipid-lowering therapy in children with Familial Hypercholesterolemia (FH). Few or no safety issues were identified.Comment: Cochrane is an international cha...

To read the full abstract: Pediatrics. 2018 Jan;141(1)Changes in biology, appearance, self-perception, behavior, and emotion make puberty one of the most pivotal phases in life. Although puberty presents challenges for all adolescents, girls who mature early are particularly vulnerable. Early pubertal timing in girls has been reported to be associated with increased prevalence and severity of ps...

To read the full abstract: Cell 2017, Volume 171, Issue 2Here, the group of Jerrold Olefsky identified adipose tissue macrophages as important sources of microRNAs regulating metabolic processes not only within the adipose tissue depot, but also in an endocrine way in other distant tissues. The application of exosomes derived from ATMs isolated from obese mice caused insulin resistance both ...

Brief summary: This prospective study, including 380 American girls followed from birth to age 15.5 years between 1991 and 2006, showed the predictive nature of age at onset of puberty for the subsequent progression and duration of pubertal maturation.Ze’ev Hochberg’s scientific and clinical curiosity is an inspiration for us all. Ze’ev approached the topic of puberty using evolutionary and developmental biology principles, according to wh...

Mol Cell Endocrinol. 2021 May 1;527:111218. doi: 10.1016/j.mce.2021.111218. PMID: 33636254This study used a high fat and high sucrose diet to generate obese mice. The offspring of these mice showed activation of the unfolding protein response and the heat-shock response in the hypothalamus as early as weaning. This was associated with malformed paraventricular nucleus axonal projections ...