ESPE Yearbook of Paediatric Endocrinology

Curr Opin Pediatr 2018, 30:734–739. DOI: 10.1097/MOP.0000000000000683• Congenital hypothyroidism is the most cost-effective screened condition.• Screening for hemoglobinopathies and glucose-6-dehydrogenase deficiency can be cost-effective in sub-Saharan Africa, India and some parts of Asia where there is a high incidence of these diseases.<p...

To read the full abstract: J Endocrinol. 2018 Jul 26.This study, using a mouse model, investigated the effects of high fat diet-induced maternal obesity on both fetal and adult offspring skeletal development.Maternal nutrition appears to influence epigenetic alterations in the offspring and to program gene expression in key metabolic pathways, such as fatty acids a...

To read the full abstract: J. Pediatr. 2018; 198:156-161See Comment under 2.7...

J Neurosci. 2020 Dec 2;40(49):9455–9466. 10.1523/JNEUROSCI.2069-20.2020. PMID: 33158965 https://www.jneurosci.org/content/40/49/9455.longIn brief: These authors used two transgenic mouse models to assess the direct action of estrogens and androgens on GHRH neurons to control growth, pubertal development and reprod...

Diabetes Care. 2021 May;44(5):1185–1193. 10.2337/dc20-3006. https://pubmed.ncbi.nlm.nih.gov/33827804/Luo et al. performed a retrospective cohort study of 159 children (age 7–11 years), including undertaking a food cue task while in the MRI scanner, to investigate whether brain reward systems are altered by in utero exposure to ...

rakeshkgyl@gmail.com J Pediatr Hematol Oncol. 2022; 44: e469-e473. PMID: 34054040.Brief Summary: This monocentric, retrospective study investigated adrenal insufficiency (AI) prevalence in a large group of children with brain tumors (BT, 398 patients) and children treated with hematopoietic cell transplantation (HCT, 268 patients). AI was diagnosed in 14 BT patients (27.4% of the 51 tested) and 14 HCT re...

To read the full abstract: Diabetes. 2019 Aug;68(8):1604–1613. doi: 10.2337/db18-1308. Epub 2019 May 24. PMID: 31127056Maternal obesity is an important risk factor for neonatal hypoglycaemia. Maternal BMI predicts the risk of neonatal hypoglycaemia independently from maternal obesity suggesting that the link between maternal adiposity and neonatal hypoglycaemia is complex. Identifying the u...

To read the full abstract: J Clin Endocrinol Metab. Vol 104, Issue 9, September 2019, Pages 3785–3794. PMID: 31127822Maternal vitamin D status during pregnancy has been associated with markers of fetal growth and development. The circulating form of vitamin D, 25-hydroxyvitamin D [25(OH)D], crosses the placenta, and the developing fetus relies on the mother for its vitamin D s...

To read the full abstract: The FASEB Journal 2019;33:12680–12695.These authors conditionally deleted the IGF1 receptor gene (IGF1R) in tenocytes using a tamoxifen-inducible Cre-recombinase system and then stimulated plantaris tendon growth in adult mice via mechanical loading. Mice that lacked IGF1R in their tenocytes showed reduced cell proliferation and tendon growth in response to mechanical loading. These studies indicate that IGF1 sign...

Lancet Glob Health 2018;6: e875–84. DOI: 10.1016/S2214-109X(18)30231-6• Perinatal chronic undernutrition plays a role in adult-onset cardiometabolic disease.• In this 40-year, longitudinal cohort in Guatemala, protein-energy nutritional supplementation during the first 2 years of life reduced the odds of diabetes but increased the risk of obesi...