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ey0015.11-9 | The brain decides weight gain | ESPEYB15

11.9 Neural correlates of familial obesity risk and overweight in adolescence

S Carnell , L Benson , KY Chang , Z Wang , Y Huo , A Geliebter , BS Peterson

To read the full abstract: NeuroImage 2017; 159: 236-247The results of this study suggest that, compared to adolescents with a low risk, lean adolescents with a high familial obesity risk show a weaker activation of neural systems subserving attentional self-regulation in response to food-denoting words. These same changes were found in overweight or obese adolescents. It is interestin...

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ey0017.11-9 | Body Weight Regulation and Insulin Sensitivity | ESPEYB17

11.9. Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity

AE O’Mara , JW Johnson , JD Linderman , RJ Brychta , S McGehee , LA Fletcher , YA Fink , D Kapuria , TM Cassimatis , N Kelsey , C Cero , ZA Sater , F Piccinini , AS Baskin , BP Leitner , H Cai , CM Millo , W Dieckmann , M Walter , NB Javitt , Y Rotman , PJ Walter , M Ader , RN Bergman , P Herscovitch , KY Chen , AM Cypess

To read the full abstract: J Clin Invest. 2020;130(5):22092219. doi: https://pubmed.ncbi.nlm.nih.gov/31961826/This clinical study addressed the chronic effects of the β3-adrenergic receptor agonist mirabegron on BAT activity, blood parameters, and insulin sensitivity in a small cohort of healthy women (n =14). Participants were treated for 4 weeks orally with mirabegron ...

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ey0016.12-14 | Lipid Metabolism | ESPEYB16

12.14. An integrative systems genetic analysis of mammalian lipid metabolism

BL Parker , AC Calkin , MM Seldin , MF Keating , EJ Tarling , P Yang , SC Moody , Y Liu , EJ Zerenturk , EJ Needham , ML Miller , BL Clifford , P Morand , MJ Watt , RCR Meex , KY Peng , R Lee , K Jayawardana , C Pan , NA Mellett , JM Weir , R Lazarus , AJ Lusis , PJ Meikle , DE James , TQ de Aguiar Vallim , BG Drew

Nature 2019;567:187193.URL https://doi.org/10.1038/s41586-019-0984-ySummary: Novel diagnostic and prognostic biomarkers in the blood that can predict early fatty liver disease were identified, using a proteomic and lipidomic-wide systems genetic approach in 107 genetically distinct mouse strains. In addition, the novel lipid-regulatory protein, PSMD9, was identified as...

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ESPE Yearbook of Paediatric Endocrinology

11.9 Neural correlates of familial obesity risk and overweight in adolescence

11.9. Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity

12.14. An integrative systems genetic analysis of mammalian lipid metabolism

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