ESPE Yearbook of Paediatric Endocrinology

AIMS Public Health 2020; 7(2): 380–392. doi: 10.3934/publichealth.2020032– Pakistan has a significantly higher prevalence of stunted children under 5 years old compared with other countries of the same income level. Stunting is more frequent in children of shorter compared to taller mothers– The authors hypothesized that higher maternal education, a modifiable factor, i...

To read the full abstract: JAMA Pediatr 2018;172:239-246Social contagion refers to the spreading of a behaviour, idea, attitude, or even an emotion, across a social group due to imitation and conformity by its members. The idea that obesity may spread due to social contagion is based on its observed clustering across networks of individuals, who are joined by ot...

To read the full abstract: J Pediatr Endocrinol Metab 2020; 33(2): 295–304. doi: 10.1515/jpem-2019-0345• Using the validated World Health Organization QOL-BREF questionnaire that independently assesses the physical, psychological, social and environmental domains, the authors assessed health-related QOL in 200 Egyptian children and adolescents with CAH.• Older patients had si...

Eur Psychiatry. 2019 Jan;55:61–66.doi: 10.1016/j.eurpsy.2018.09.003. PubMed ID: 30390473Is the prevalence of gender dysphoria today truly increasing, or do the increasing numbers result because today’s world is more open so that these individuals and families no longer hide in the closet? Or are methodological factors playing a role? Fact is that in Eu...

Journal of Clinical Endocrinology and Metabolism. 2018; 103(6): 2403–7.URL: http://www.ncbi.nlm.nih.gov/pubmed/29659879Summary: Orlistat therapy reduced serum triglycerides by 50–60% in two children with Type 1 hyperlipoproteinemia (T1HLP) in a randomized, open-label, crossover trial with four periods and two sequences. The treatment was safe and is suggested as fir...

To read the full abstract: Dev Cell. 2018 Nov 5;47(3):294–305.e7.Steroid hormones were believed to enter target cells via passive diffusion through the plasma membrane. This article shows that, at least for Drosophila, steroid hormones require a protein transporter to enter cells.Genomic functions of steroid hormones are mediated by intracellular nuclear recep...

Horm Behav. 2020;126:104849. 10.1016/j.yhbeh.2020.104849. https://www.sciencedirect.com/science/article/abs/pii/S0018506X20301756?via%3DihubIn brief: This study used functional MRI to compare resting state functional connectivity in women who started oral contraception during puberty or ad...

Brief summary: This in vivo study identifies a new gene, CDYL (Chromodomain Y-like protein) in the epigenetic control of sex determination in mice.Recent findings on mammalian sex development suggest that the fate decision of bipotential gonads depends not only on transcriptional activation of Y-linked testis-determining gene (SRY/Sry) but also on a delicate expression balance between the mutually antagonistic pro-testis and pro-ovarian genes. P...

Brief summary: This literature review summarized the recent advances in our understanding of the GnRH system throughout life and its implication in the brain development beyond its conventional role in reproductive control.During embryonic development GnRH neurons migrate from the olfactory placode to the hypothalamus, where they control the hypothalamus–pituitary–gonadal axis (1,2). But many GnRH neurons migrate to other brain regions, such as...

Brief summary: This comprehensive narrative review provides a “Seminar” on congenital adrenal hyperplasia (CAH). The authors performed a thorough comprehensive qualitative summary of articles published mainly in Cochrane Library, MEDLINE, and Embase in English between Jan 1, 2005, and June 30, 2021, while not excluding commonly referenced and highly regarded older publications.Congenital adrenal hyperplasia (CAH) is an ‘umbrella’ clin...