ESPE Yearbook of Paediatric Endocrinology

Front Endocrinol (Lausanne). 2022 Mar 24;13:832678. doi: 10.3389/fendo.2022.832678. PMID: 35399939.Brief Summary: This retrospective case note study assessed the impact of different classes of obesity on maternal and neonatal outcomes. Higher classes of maternal obesity were associated with increased rates of caesarean section, GDM and gestational hypertension and pre-eclampsia.<p class...

Brief summary: This study analyzed cross-sectional data on almost 5,000 adolescents from the Adolescent Brain Cognitive Development (ABCD) cohort data (https://abcdstudy.org/), including resting state functional MRI, structural MRI and neurocognitive task scores. Excess BMI in young adolescents was associated with profound aberrant topological alterations in maturating functional circuits, as well as with underdeveloped brain structures that may adversely impact cogni...

To read the full abstract: Pediatr Diabetes. 2020;21(2):224–32. doi: 10.1111/pedi.12976Short summary: This high-quality, longitudinal lifestyle intervention, with ample funding, had little effect on improving health behaviour profiles of adolescents with T2DM.Comment: The first sweeping recommendation for adolescents with obesity, and certainly for ...

Cochrane Database Syst Rev. 2021 Apr 19;4:CD009951. doi: 10.1002/14651858.CD009951.pub3. PMID: 33870484.In summary, this review did not find certain evidence to support the use of probiotics to reduce the risk of GDM. Only 2 studies suggested a possible reduction in the risk of GDM with probiotics. More importantly, and of concern, the review found a high degree of certainty that th...

J Neurosci. 2020 Dec 2;40(49):9455–9466. 10.1523/JNEUROSCI.2069-20.2020. PMID: 33158965 https://www.jneurosci.org/content/40/49/9455.longIn brief: These authors used two transgenic mouse models to assess the direct action of estrogens and androgens on GHRH neurons to control growth, pubertal development and reprod...

Int J Obes (Lond). 2020 Oct;44(10):2011–2022. 10.1038/s41366-020-0644-1. https://pubmed.ncbi.nlm.nih.gov/32713944/Schur et al. addressed the question, whether responsiveness to visual food cues in functional magnetic resonance imaging (fMRI) is related to the treatment success of a 6-month Family-based Behavioral Treatment (...

Obesity (Silver Spring) 2020 Aug;28(8):1512–1518. https://pubmed.ncbi.nlm.nih.gov/32935936/These authors analysed a cohort of n=399 overweight and obese children (age 2–12 years), who underwent a 1-year lifestyle intervention, to test whether possible alternatives to the BMI z-score (%BMIp95, %BMIp50, BMImz) might correlate better with changes in % total body fat (%BF) a...

Christian.roth@deattlechildrens.org J Clin Endocrinol Metab. 2022; doi: 10.1210/clinem/dgac299. https://pubmed.ncbi.nlm.nih.gov/35544121/Brief Summary: In this intervention study, the effect of a 24-week family-based behavioral obesity intervention on brain activation, measured by v...

Abstract: Endocrinology. 2018 Mar 1;159(3):1469–1478.In brief: In this article, a combination of microdissection, miroRNA profiling and transfection studies identify 3 microRNAs that are highly expressed in the proliferative zone and appear to be down-stream mediators of PTHrP signaling in the growth plate.Comment: In the growth plate, P...

Brief summary: Using data on 4964 type 1 diabetes (T1D) cases and 7497 controls, this study assessed whether the effect of common genetic variants (SNPs) on risk of T1D is mediated through trans-effects on the expression of core genes. Nine putative core genes were identified, all implicated in immune system regulation. In addition, four T1D-associated genomic regions were identified as master regulators that have trans-effects on gene expression.<p class="abstext...