ESPE Yearbook of Paediatric Endocrinology

anton.holmgren@regionhalland.se Pediatr Res. 2021 Jul;90(1):184–190. doi: 10.1038/s41390-020-01234-3.Brief Summary: This observational study compared the pubertal growth spurt of children in a Spanish study group with severe early onset obesity to children in a Swedish community-based study. The authors show that childhood obesity i...

Ashley.H.Shoemaker@VUMC.org International Journal of Obesity 2022, Epub 2022 Jan 3. doi: 10.1038/s41366-021-01043-6. https://pubmed.ncbi.nlm.nih.gov/34975146/Brief Summary: This double-blind, placebo-controlled trial assessed the efficacy of 36 weeks of GLP1RA treatment with exenatide e...

grahamo@diabetesnsw.com.au Diabetes Res Clin Pract 2022, 183:109083. doi: 10.1016/j.diabres.2021.109083Brief Summary: The incidence of Type 1 diabetes (T1D) in children and adolescents is increasing in many nations. The 10th edition of the International Diabetes Federation Atlas reports that an estimated 108,300 youth aged < 15 years a...

To read the full abstract: J Sex Med. 2020, Apr; 17: 570–84. doi: https://www.ncbi.nlm.nih.gov/pubmed/32111534This position statement provides an update for health-care professionals on recommended basic principles for care of transgender people, including male, female and nonbinary. It uses a developmental approach to describe the best care for prepubescent, pubescent and adolescen...

Abstract: Endocrinology. 2018 Mar 1;159(3):1469–1478.In brief: In this article, a combination of microdissection, miroRNA profiling and transfection studies identify 3 microRNAs that are highly expressed in the proliferative zone and appear to be down-stream mediators of PTHrP signaling in the growth plate.Comment: In the growth plate, P...

To read the full abstract: Sci Rep. 2019 Apr 30; 9(1): 6691.In recent years, improved knowledge of the metabolic risks in childhood cancer survivors (CCS) has increasingly focused research on modifiable factors and preventive strategies (1–2). It is well known that therapeutic irradiation can cause detrimental changes in body composition, but it is still unknown whether the specific...

To read the full abstract: Lancet Diabetes Endocrinol 2018; 6(2):95-104As non-communicable diseases (NCDs) are reaching epidemic levels, emerging data elucidate the devastating non-metabolic long-term risks of overweight, obesity and diabetes. Using published relative risk analysis and cancer incidence estimates from the GLOBOCAN project, the authors provide a thorough risk analysis of si...

To read the full abstract: Horm Res Paediatr. 2018; Jul 26:1-1As the global burden of non-communicable diseases (NCD) is rising to epidemic levels worldwide, efforts are underway to build capacity for childhood NCDs in low- and middle-income countries (LMICs), including among health care providers in pediatric endocrinology. With increased ability to recognize and diagnose pediatric endocrine conditi...

Brief summary: Patients with congenital hypothyroidism have a higher rate of comorbidities in adult age (1). This nationwide population-based register study aimed at investigating the incidence of comorbidities present at birth or acquired during childhood in patients with congenital hypothyroidism and prescription of specific drugs (antidepressants, antipsychotics, medication for ADHS).The study analyzed data from n=438 full-term patients with ...

In Brief: These authors identify a frameshift truncating variant in the gene SPIN4 (Spindlin member 4) in a patient with skeletal overgrowth, hepatosplenomegaly and macrocephaly. Using state-of-the-art mouse models and histone peptide arrays, they delineate the underlying pathogenic mechanism and show that SPIN4 positively regulates Wnt signalling by functioning as an epigenetic reader.Commentary: Generalized overgrowth disorders are ch...