ESPE Yearbook of Paediatric Endocrinology

Diabetes Care. 2021 Nov;44(11):2536-2541. doi: 10.2337/dc21-0327. PMID: 34475030.Brief Summary: This retrospective case control study investigated changes in the metabolic profile in newborn screening of infants born to mothers who had been treated with metformin. Treatment with metformin during pregnancy was associated with subtle changes in metabolites in the newborn screening.<p class="abste...

shenali.amaratunga@fnmotol.cz Horm Res Paediatr 2022; 95:1–11. doi: 10.1159/000521210Brief Summary: This review highlights the value of consanguinity in the discovery of novel genes for three endocrine conditions with increasing pathophysiological complexity: congenital hyperinsulinism, monogenic diabetes and short stature.<p class="abstex...

Nat Hum Behav. 2022;6(1):97-110. doi: 10.1038/s41562-021-01169-7. PubMed ID: 34413509Brief summary: This cross-sectional study of adults (N=702) aged 58–98 measured cognitive abilities across a range of domains (alerting, orienting and executive inhibitory networks) by use of a computer-based Attention Network Test. In non-linear regression models, while efficiency of the ale...

To read the full abstract: Nat Rev Endocrinol. 2020; 16(5): 284–296. PMID: 32203405.The adrenal gland is the primary source of 11-oxygenated 19-carbon steroids, also termed 11-oxyandrogens, which have several roles in human physiology and disease. These include 11β-hydroxyandrostenedione (11OHA4), 11-Ketotestosterone, (downstream metabolite of 11OHA4, mostly produced in peripheral...

To read the full abstract: BMJ Case Rep 2020;13:e231737. doi: 10.1136/bcr-2019-231737• The authors report 2 cases of severe short stature, Laron Syndrome and Cornelia-Delange-like syndrome, followed in Ecuador, a country with limited resources.• They highlight the tendency of a society to discuss children with severe short stature with derogatory terms to automatically assume tha...

To read the full abstract: Acta Biomed. 2019; 90(2): 316–320. doi: 10.23750/abm.v90i2.8485• The authors review the present status of newborn screening in Africa and discuss the concept that adding a neonatal screening for congenital hypothyroidism (CH) to an existing sickle cell disease screening would make it easier to implement than developing an independent screening program.&...

Endocrine Reviews, Volume 40, Issue 4, August 2019, Pages 857–905doi: 10.1210/er.2018-00140. PMID: 30590466This encyclopedic article reviews the molecular and organizational events that take place during testicular development from the very early start, i.e. the development of the primordial germ cells before gastrulation and of the gonadal ridges at 3–4 week...

To read the full abstract: Pediatr Diabetes. 2018 Jun;19(4):832–839This diabetes team are well known for, and should be applauded for, their holistic approach to diabetes care. Also, the group always points to central aspects of daily routine clinical practice and analyzes critical issues in pediatric diabetes. The aim of this study was to examine whether or not clinician qualities ...

Lancet Diabetes Endocrinol 2019 Published Online March 13, 2019. DOI: 10.1016/S2213-8587(19)30083-X• Practical challenges associated with diabetes care in humanitarian contexts in low- and middle- income countries abound.• In this position paper, the authors articulate the important needs around diabetes care in the context of the 6 building blocks ...

To read the full abstract: JAMA Pediatr 2018;172:57-64Corticosteroids are a well-known risk factor for compromised bone health. There have been concerns regarding the use of inhaled corticosteroids in children with asthma. It is often stated that poor disease control is a greater risk for bones than the medication itself. The evidence however has not been overwhelming. Corticosteroids ...