ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Pediatrics. 2018 Apr;141(4)See comment on 6.8....

To read the full abstract: Food & Function 2018;9:1944-1966"Functional foods" are foods that have a potentially positive effect on health beyond basic nutrition. Oatmeal is a familiar example of a functional food as it contains soluble fiber that can lower cholesterol levels. Foods are often modified to have health benefits, for example fortified orange juice with calcium to improve bone health....

To read the full abstract: Journal of Human Evolution 2018;114:131-140Whereas the age at onset of puberty in the chimpanzee is not of much concern to most of us, the results show an interesting aspect. On average, the first birth is delayed by 3.4 years after menarche. This period of 'emerging adulthood', should be included in models of apes, as well as human maturation where it lasts for ...

Brief summary: PTEN hamartoma tumor syndrome is one of five well known genetic syndromes associated with differentiated thyroid carcinoma (1,2). PTEN hamartoma tumor syndrome comprises four different entities: Cowdwn syndrome, Bannayan-Riley-Ruvalcaba syndrome, PTEN-related Proteus syndrome, and Proteus-like syndrome caused by mutations in the PTEN (phosphatase and tensin homologue) tumor suppressor gene [3]. This prospective longitudinal mu...

PLoS One. 2020 Jun 26;15(6):e0234970. doi: 10.1371/journal.pone.0234970.In brief: Metabolite signatures were compared between children with normal weight, obesity, and both obesity and T2DM, by measuring 273 analytes in fasting plasma and a 24-hour urine sample. Twenty-two urine metabolites were uniquely associated with T2DM. Adolescents with T2DM have altered purine nucleoti...

J Clin Endocrinol Metab. 2022;107(7):1965-75. doi: 10.1210/clinem/dgac173.PubMed ID: 35323957Brief summary: This population-based birth cohort study related infancy serum testosterone concentrations at age 3 months to parameters of reproductive function at age 18 to 20 years in 259 males. Serum testosterone in infancy predicted adult total sperm counts, and other reproductive hormones and geni...

To read the full abstract: Support Care Cancer. 2020 Feb 11. Epub ahead of print. hess2@phoenixchildrens.comThe development of a second neoplasia is a major concern during the follow-up of childhood cancer survivors (CCS). Secondary cancers account for nearly 50% of non-relapse mortality at 5 years. Thyroid tumours represent 10-20% of subsequent neoplasia cases, due to the high sensitivity of the g...

To read the full abstract: Cell Reports. 2018 Dec 4;25(10):2643–2652.e4.More on the gut and the reward response: Ghrelin has been reported to encourage eating through dopamine that is important for the reward response. Here, the authors injected 38 subjects with ghrelin, while exposing them to various odors, both food and non-food based. They were also shown r...

To read the full abstract: Physiol Res. 2018 May 4;67(2):331-337See Comment under 2.10...

To read the full abstract: J Pediatr Endocrinol Metab 2018; 31(6):601-608This article summarizes the findings of likely the largest program of neonatal congenital hypothyroidism (CH) screening in the world. This is a truly impressive effort. The overall incidence of CH was 1/2421, in line with other reports that also observed a relatively high incidence of CH in neonates born in Asia. However, a...