ESPE Yearbook of Paediatric Endocrinology

Front Endocrinol (Lausanne). 2020; 11: 558897. https://pubmed.ncbi.nlm.nih.gov/33042019/This patient cohort study evaluated the prevalence of autoimmune thyroid diseases (AITDs), defined as decreased thyroid echogenicity in 61 children with Crohn’s disease, 25 infliximab (IFX)-naïve (control group) and 36 IFX-treated patients (mean duration of IFX therapy 13.9±16.6 months). T...

Obesity (Silver Spring) 2021 Jan;29(1):56–61.https://bit.ly/2Sz4SBzOxytocin was investigated in this small experimental study for its potential benefits on obesity. To test oxytocin for suppression of behavioural impulses, 10 men with overweight or obesity were subjected to a task assessing ability and strategy to suppress behavioural impulses. After receiving intranasal oxytocin, compared with placebo, ...

J Clin Endocrinol Metab. 2022 Jan 1;107(1):e246-e253. doi: 10.1210/clinem/dgab601. PMID: 34407200.Brief Summary: This retrospective single center study in neonates with hyperinsulinaemic hypoglycaemia examined the utility of real-time continuous glucose monitoring (CGM). CGM is best placed as an adjunct to routine intermittent blood glucose monitoring, providing information on glucose trends d...

Front Endocrinol (Lausanne). 2021 Jun 11;12:657873. doi: 10.3389/fendo.2021.657873. PMID: 34177802.Brief Summary: This is a single case report describing a possible new candidate gene (ADCY7) for congenital hyperinsulinism. Mutations in the ADCY7 gene may be a new cause of congenital hyperinsulinism but more cases are needed and the molecular mechanisms studied in more det...

Stem Cell Res. 2021 Jul;54:102433. doi: 10.1016/j.scr.2021.102433. PMID: 34171785.Brief Summary: This study generated induced pluripotent stem cells (iPSCs) from a patient with permanent neonatal diabetes mellitus (PNDM) due to Fanconi-Bickel syndrome. This iPSC line provides a novel human cell model to understand the pathophysiology of FBS and diabetes mellitus and for the potential of dev...

J Clin Endocrinol Metab. 2021 Nov 19;106(12):e5075-e5087. doi: 10.1210/clinem/dgab528. PMID: 34272865.Brief Summary: This national birth registry study in Denmark collected data on gestational diabetes and adverse pregnancy outcomes in relation to country of origin of the mother. Country of origin and the number of births were associated with adverse effects from gestational diabetes.<p cl...

Transl Psychiatry. 2022; 12(1): 132. PMID: 35354798https://pubmed.ncbi.nlm.nih.gov/35354798/Brief Summary: This case control study identified widespread effects of fetal exposure to antenatal maternal glucocorticoid treatment on newborn bloodspot DNA methylation profiles.Antenatal treatment with glucocorticoids (AGC), such as betamethasone or dexamethasone, is widely u...

Diabetes Care 2021;44:1898-1905. https://pubmed.ncbi.nlm.nih.gov/34285100/Brief Summary: This systematic review and meta-analysis of 46 studies and 6,468 participants (aged <20 years) provides evidence that youth with type 1 diabetes (T1D) have reduced lower body mineral density (BMD), as assessed by multiple modalities: DXA, peripheral quantitative computed tomography (pQCT), and/or qu...

To read the full abstract: Diabetes Care. 2020 Apr;43(4):906–908. doi: 10.2337/dc19-2126. Epub 2020 Jan 23. PMID: 31974101Antenatal corticosteroid administration prior to planned cesarean section in early labour reduces by >50% the risk of admission to the neonatal intensive care unit for respiratory distress syndrome and transient tachypnea of the newborn. However, among pregnant women wit...

To read the full abstract: J Bone Miner Res 2019;34(8):1387–1392.In brief: Cell tracing of the growth plate chondrocytes most adjacent to the perichondrium demonstrate that they transit into the metaphysis and contribute to the pool osteoblasts and reticular stromal cells of the bone marrow during growth in young mice.Commentary: Borderline chondrocytes are the growth plate chondrocytes located as a ...