ISSN 1662-4009 (online)

ey0019.11-4 | New findings in adipose tissue biology | ESPEYB19

11.4. Expression of the adipocyte progenitor markers MSCA1 and CD36 is associated with adipose tissue function in children

M Hanschkow , N Boulet , E Kempf , A Bouloumie , W Kiess , R Stein , A Korner , K Landgraf

kathrin.landgraf@medizin.uni-leipzig.de JCEM 2022; 107(2): e836–e851https://pubmed.ncbi.nlm.nih.gov/34448000Brief Summary: This study investigated the association of the novel adipose-derived stem cell (ASC) markers Mesenchymal Stem cell Antigen 1 (MSCA1) and CD36 with adipose tissue function in samples collected from children...

ey0019.11-11 | Weight regulation and endocrine circuits (including interventions) | ESPEYB19

11.11. The pubertal growth spurt is diminished in children with severe obesity

A Holmgren , GA Martos-Moreno , A Niklasson , J Martinez-Villanueva , J Argente , K Albertsson-Wikland

anton.holmgren@regionhalland.se Pediatr Res. 2021 Jul;90(1):184–190. doi: 10.1038/s41390-020-01234-3.Brief Summary: This observational study compared the pubertal growth spurt of children in a Spanish study group with severe early onset obesity to children in a Swedish community-based study. The authors show that childhood obesity i...

ey0019.11-13 | Weight regulation and endocrine circuits (including interventions) | ESPEYB19

11.13. Weight gain and obesity rates in transgender and gender-diverse adults before and during hormone therapy

M Kyinn , K Banks , SY Leemaqz , E Sarkodie , D Goldstein , MS Irwig

mirwig@bidmc.harvard.edu Int J Obes (Lond). 2021 Dec;45(12):2562–2569. doi: 10.1038/s41366-021-00935-x. Epub 2021 Aug 16. PMID: 34400797. https://pubmed.ncbi.nlm.nih.gov/34400797/Brief Summary: This retrospective chart review of 470 ethnically diverse transgender and gender diverse in...

ey0019.13-4 | Improving access to healthcare in pediatric endocrinology and diabetes | ESPEYB19

13.4. A human rights-based approach to improve access to insulin and other aspects of diabetes care

F Brennan , P Williams , K Armstrong , E Klatman , N Donelan , GD Ogle , A Eussen , AJ Jenkins

fpbrennan@ozemail.com.au Diabetes Res Clin Pract 2022; 183: 109153. doi: 10.1016/j.diabres.2021.109153Brief Summary: In this perspective, the authors argue that a human rights-based approach to access to insulin empowers patients, families, and communities living with diabetes, and grounds actions by governments, clinicians, and non-governme...

ey0019.13-11 | Diabetes | ESPEYB19

13.11. Validation study and outcomes of the diabetes quality of life in youth instrument in Haitian youth with type 1 diabetes residing in Haiti

Y Victor , V Lorgeat , B Coriolan , Z Kamal , R Vincent , JE von Oettingen , K Altenor

julia.vonoettingen@mcgill.ca Can J Diabetes 2022: 46; 32e39. doi: 10.1016/j.jcjd.2021.04.010Brief Summary: This validation study and survey showed that the Diabetes Quality of Life for Youth (DQOLY) questionnaire and the EuroQol Visual Analogue Scale (EQ-VAS) are valid measures of Health-Related Quality of Life in Haitian youth with type 1 ...

ey0019.14-4 | Steroidogenesis and beyond | ESPEYB19

14.4. Quantification of androgens and their precursors in full-term human placenta

T Yoshida , K Matsumoto , M Miyado , Y Miyashiro , H Sago , R Horikawa , M Fukami

Eur J Endocrinol 2021;185:K7–K11 doi: 10.1530/EJE-21-0312Brief Summary: Steroid profiling of 10 placentas of healthy full-term neonates (five male and five female) using liquid chromatography-tandem mass spectrometry revealed the presence of C11-oxy C19 steroids (androgens) in the fetal-placental unit at term – pointing to alternative androgen pathways in this unit.<p cla...

ey0017.2-4 | Neonatal Hypoglycaemia | ESPEYB17

2.4. Targeting glucose control in preterm infants: Pilot studies of continuous glucose monitoring

L Thomson , D Elleri , S Bond , J Howlett , DB Dunger , K Beardsall

To read the full abstract: Arch Dis Child Fetal Neonatal Ed. 2019 Jul;104(4):F353–F359. PMID:30232094.In preterm and in the very low birthweight infants, hyperglycaemia is associated with increased risks of mortality, brain injury, retinopathy of prematurity and worse neurodevelopmental outcomes (1). Treatment of hyperglycaemia with continuous insulin infusion leads to increas...

ey0017.2-12 | Updates on the Genetics of Neonatal Diabetes Mellitus, Congenital Hyperinsulinism and Glucose Disorders | ESPEYB17

2.12. Ion Transporters, channelopathies, and glucose disorders

H Demirbilek , S Galcheva , D Vuralli , S Al-Khawaga , K Hussain

To read the full abstract: Int J Mol Sci. 2019 May 27;20(10). pii: E2590. doi: 10.3390/ijms20102590. PMID:31137773.Ion channels and transporters play essential roles in excitable cells, including cardiac, skeletal and smooth muscle cells, neurons, and endocrine cells. In pancreatic beta-cells, KATPchannels link the metabolic signals generated inside the cell to changes in the beta-cell membra...

ey0017.2-16 | Gestational Diabetes Mellitus: Neonatal and Long-term Consequences | ESPEYB17

2.16. Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner

Z Carlson , H Hafner , M Mulcahy , K Bullock , A Zhu , D Bridges , E Bernal-Mizrachi , B Gregg

To read the full abstract: Am J Physiol Endocrinol Metab. 2020 May 1;318(5):E600–E612. doi: 10.1152/ajpendo.00473.2019. Epub 2020 Mar 10. PMID: 32154743The window of lactation is a critical period during which nutritional and environmental exposures may impact lifelong risks of metabolic diseases (such as type 2 diabetes and obesity). Significant organ and tissue development, organ...

ey0017.6-19 | Transgender Medicine: Brain and Psychology | ESPEYB17

6.19. Does sex hormone treatment reverse the sex-dependent stress regulation? A longitudinal study on hypothalamus-pituitary-adrenal (HPA) axis activity in transgender individuals

J Fuss , L Claro , M Ising , SV Biedermann , K Wiedemann , GK Stalla , P Briken , MK Auer

To read the full abstract: Psychoneuroendocrinology. 2019, Jun; 104: 228–37. doi: https://www.sciencedirect.com/science/article/pii/S0306453018312307?via%3DihubThe effect of sex hormones on long-term regulation of the hypothalamic-pituitary-adrenal (HPA) axis was studied in 25 transgender individuals (10 trans-female) at baseline and after 3 months ...