ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Development 2017; 144:3533-3546Endochondral ossification is the process by which the embryonic cartilaginous scaffold of most bones is gradually replaced by bone. During this process chondrocytes proliferate, undergo hypertrophy and maturation and form the growth plate, essential for bone growth. Postnatal bone growth is tightly regulated by both systemic and lo...

To read the full abstract: J Psychosom Res. 2017 Oct;101:122-127The results of this study clearly show individuals with a DSD condition have psychological difficulties, and not only in countries with a less well developed health care systems, as reported by Khorashad et al. 2018. The findings indicate that having a DSD may impose a type of stress and vulnerability that is more common t...

To read the full abstract: Dig Dis Sci. 2017;62:3110-3116This retrospective single-centre study is the first to report the impact of anti-tumor necrosis factor (anti-TNF) therapy on weight gain in children with inflammatory bowel disease (IBD). The results are consistent with data in adults, in whom weight gain during anti-TNF treatment was negatively correlated to pre-treatment BMI (1). A si...

To read the full abstract: Diabetes Care. 2017;40:1614-1621See comment on 10.10...

To read the full abstract: NeuroImage 2017; 159: 236-247The results of this study suggest that, compared to adolescents with a low risk, lean adolescents with a high familial obesity risk show a weaker activation of neural systems subserving attentional self-regulation in response to food-denoting words. These same changes were found in overweight or obese adolescents. It is interestin...

To read the full abstract: Int J Obes 2018; 42: 115-118Intragastric balloons have now been used for more than 30 years in the treatment of extreme obesity. There are more than 30 studies published with almost 5,000 patients on the efficacy and safety of gastric balloons. However, due to several, sometimes severe side effects and the lack of convincing long-term outcomes, this treatment approach ha...

To read the full abstract: N Engl J Med 2018;378:1302-1312.While it is well known that being overweight in childhood and early adulthood is linked to a higher risk of T2DM later in life, the question arises as to whether diabetes risk would change if overweight children lose weight. This large-scale longitudinal study demonstrated that men who had remission of overweight between ages 7 and 13 yea...

To read the full abstract: Int J Endocrinol Metab 2017; 15(3):e55451Systematic neonatal screening for congenital hypothyroidism (CH) was first proposed by Dr Jean Dussault, a Canadian (adult) endocrinologist, in 1974. It was rapidly implemented in most high-income countries in the late 1970’s and 1980’s. Ideally, a screening program should be highly sensitive (able to ...

To read the full abstract: Front Endocrinol (Lausanne) 2017;8:170Increasing sedentary behaviours and availability of high energy dense processed foods are the obvious culprits to explain the trends towards more overweight and obese populations around the world. However, we should remember that many other hypotheses are proposed, including higher ambient room temperatures due to ce...

To read the full abstract: N Engl J Med 2017;377:2228-2239Paediatric endocrinologists often prescribe oral hormonal contraception preparations as these are convenient options for the management of various conditions in adolescent girls (e.g. polycystic ovary syndrome features, hypogonadism). Therefore, we should understand the possible adverse effects. This huge national database st...