ESPE Yearbook of Paediatric Endocrinology

Publisher: W&N (18 Mar. 2021). ISBN-10: 1474619967The authors describe this book as ‘a short, practical, timely guide to the tools you need to understand the numbers we read in the news everyday - and how we often get them wrong’.One of the societal consequences of the COVID-19 pandemic has been the rising public interest in numbers and statistics. ‘Armchair experts’ in statistics and epidemiology are no lon...

Nature 2021; 592: 428–432https://www.nature.com/articles/s41586-021-03417-2These authors report that in mice the stress hormone corticosterone (the rodent equivalent of cortisol in humans) acts on dermal papillae to suppress expression of Gas6 (encoding growth arrest specific 6) and thereby cause hair follicle stem cell (HFSC) quiescence and reduced hair growth. They show that...

Nature 2020; 583: 596–602https://www.nature.com/articles/s41586-020-2499-yIn order to understand the cellular processes that underlie ageing, the authors performed plasma proteomics at 10 different ages across the lifespan of the mouse. They integrated these data with a parallel large study published alongside this paper in the same edition (1), which describes the ‘Mouse ...

JAMA. 2020; 323(19): 1924-1933. https://jamanetwork.com/journals/jama/fullarticle/2766162The authors assembled a retrospective population-based cohort using nationwide registries of births and public specialized medical care settings in Finland in order to study whether antenatal corticosteroid treatment is associated with mental and behavioral disorders in children. Antenat...

One Earth, Volume 3, Issue 4, 23 October 2020, Pages 480-490 https://bit.ly/3vFcRueBy integrating past climate and fossil databases, these authors suggest that climate change was the primary factor in the extinction of Homo species.Homo erectus, H. heidelbergensis and H. neanderthalensis all became extinct. Why? And are we going that way too? The authors claim that cli...

Science 2020 Sep; 369(6509): eaba3066https://bit.ly/3wMzM8xBy integrating sex-specific Genotype-Tissue Expression (GTEx) data with gene function and transcription factor binding annotations, these authors describe mechanisms contributing to sex differences in the human transcriptome.Many complex human traits and diseases exhibit sex-specific characteristics. These sex differences have b...

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Diabetologia. 2021 Jun;64(6):1342–1347. 10.1007/s00125-021-05428-0. https://pubmed.ncbi.nlm.nih.gov/33830302/By studying data from very large-scale genome-wide association studies (GWAS) in European ancestry individuals, the authors compared genetic signals that confer risk of type 1 (T1DM) and type 2 diabetes (T2DM). Only 5 signals ...

Nature. 2021 volume 594, 398–402https://www.nature.com/articles/s41586-021-03552-wThe authors report a large genome-wide association study (GWAS) of type 1 diabetes (T1D) in 18 942 cases and 501 638 controls, finding 92 T1D-associated genomic loci (59 known and 33 novel). Furthermore they analyse DNA chromatin patterns in pancreas and peripheral white blood cells to help ident...

Journal of Clinical Endocrinology & Metabolism, 2020. Vol 105(8), 2789–2802. doi: https://doi.org/10.1210/clinem/dgaa354The authors performed a randomized crossover trial of Late Dinner (22:00 hours) vs Routine Dinner (18:00) in a laboratory setting in 20 healthy adult volunteers. Meal contents and sleep period (23:00-07:00) were kept the same in both arms and sleep patterns were u...