ESPE Yearbook of Paediatric Endocrinology

Brief summary: In this multicenter, open-label, parallel-group, randomized trial, 97 adolescents (aged 10–16.9 years) were randomized within 21 days after the diagnosis of type 1 diabetes (T1D) to receive either hybrid closed-loop therapy or standard insulin therapy (control) for 24 months. Although closed-loop therapy was associated with better glycemic outcomes, there were no differences in C-peptide between the two groups.The Closed Loop from Ons...

In Brief: This manuscript was prepared from presentations given at the ESPE New Inroads for Child Health (NICHe) conference held in May 2009 in Marstrand, Sweden. It reviewed the concept of plasticity in developmental programming and evidence for the role of epigenetic mechanisms. It became widely accepted as a leading reference on this topic with currently >750 citations in Google Scholar.Comment: Ze’ev Hochberg had a brilliant, creative mind. ...

J Clin Endocrinol Metab. 2020 Nov 1;105(11):dgaa563. doi: 10.1210/clinem/dgaa563. PMID: 32818257.This manuscript describes an unusual case of a baby born with a homozygous Nkx2.2 mutation who developed severe neonatal diabetes mellitus and then on follow up went onto develop severe obesity characterized by marked hyperphagia.Nkx2.2 is an important transcription factor...

Eur J Endocrinol. 2020;183:637–645. doi: 10.1530/EJE-20-0617.This study provides for the first time clear evidence that the block and replace (BR) strategy (combination of carbimazole plus levothyroxine) is not superior to the carbimazole dose titration (DT) strategy for treatment of paediatric Graves’ disease.Wood et al. present the first randomized c...

Blood Rev. 2021; 45: 100730. https://pubmed.ncbi.nlm.nih.gov/32654893/This practical treatment protocol was developed by an experienced multidisciplinary team following a critical and updated systematic review of the literature.Hypogonadism is a common finding after antineoplastic treatment. It can either result from a primary gonadal disorder (due to pelvic irradiati...

Diabetes Res Clin Pract. 2020;168:108372. doi: 10.1016/j.diabres.2020.108372Here, the Italian Society for Pediatric Endocrinology and Diabetology carried out a literature search in Medline and Embase and also Diabetes Societies websites until May 21st, 2020 for guidelines and recommendations on T1D management during the COVID-19 pandemic. They state that there is currently no evidenc...

PLoS One. 2020 Jun 26;15(6):e0234970. doi: 10.1371/journal.pone.0234970.In brief: Metabolite signatures were compared between children with normal weight, obesity, and both obesity and T2DM, by measuring 273 analytes in fasting plasma and a 24-hour urine sample. Twenty-two urine metabolites were uniquely associated with T2DM. Adolescents with T2DM have altered purine nucleoti...

Health Qual Life Outcomes 2020; 18: 258. doi: 10.1186/s12955-020-01515-9– The authors compared the quality of life (QOL) in 59 patients with CAH raised as females to 57 female patients with diabetes– Patients with CAH included 12 children, 29 adolescents and 18 adults– They found that the health-related QOL of female patients with CAH was similar to the QOL of patients wi...

J Clin Endocrinol Metab. 2022 Feb 17;107(3):638-648. doi: 10.1210/clinem/dgab798. PMID: 34726229Brief Summary: This large monocenter retrospective cohort study (n=469) of patients diagnosed with congenital hypothyroidism (CH) identified predictors of transient vs. permanent CH. The authors developed a 4-item risk score (0-13 points) to be used from the age of 12 months on to predict t...

Pediatr Nephrol, 2022. 37(4): p. 859-869 PMID: 34542703Brief Summary: This prospective observational cohort study investigated growth rate after kidney transplant in children with chronic kidney disease (CKD) and growth failure, who received or did not receive rhGH treatment before transplantation. Patients pre-treated with rhGH showed better growth rates with taller height SDS at 7 years after transplantation. Positive effects of pre-transplant...