ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Dev Cell. 2018 Nov 5;47(3):294–305.e7.Steroid hormones were believed to enter target cells via passive diffusion through the plasma membrane. This article shows that, at least for Drosophila, steroid hormones require a protein transporter to enter cells.Genomic functions of steroid hormones are mediated by intracellular nuclear recep...

To read the full abstract: Indian J Pediatr 2018; 85(6):440-447In 2017, the population of India was estimated at 1.28 billion. With a birth rate of 19/1000, it means that 24.4 million babies are born each year in India. More than half of the births take place at home, in particular in rural India. Assuming an incidence of 1:2500 for congenital hypothyroidism (CH), close to 10,000 babies are b...

To read the full abstract: Lancet 2017; 390(10113):2627-2642Over the past 10 years, the prevalence of Type 2 diabetes (T2DM) has increased disproportionately in Africa, South East Asia, the Middle East and the Asia Pacific region. Interestingly, although we need more studies investigating the prevalence of T2DM in Latin America, the prevalence of T2DM in youth living in these countries do...

J Adolesc Health. 2020 Jun;66(6):658–665. doi: 10.1016/j.jadohealth.2020.01.007.https://www.ncbi.nlm.nih.gov/pubmed/32115323This systematic review is inspired by the large discordance between the high number of transgender individuals who express a desire for genetic parenthood compared to the very low number who ult...

Diabetes Metab Syndr. 2020;14(5):1213–1216. doi: 10.1016/j.dsx.2020.07.016In this small cross-sectional study on 52 pediactric patients with T1D, a structured questionnaire was administered on follow up within 15 days after lockdown during the COVID-19 pandemic. Of these 52 patients, 36.5% had hyperglycemic and 15.3% had hypoglycemic episodes. Insulin dose was missed in 26.9%, gluco...

J Clin Endocrinol Metab. 2022 Jan 1;107(1):e246-e253. doi: 10.1210/clinem/dgab601. PMID: 34407200.Brief Summary: This retrospective single center study in neonates with hyperinsulinaemic hypoglycaemia examined the utility of real-time continuous glucose monitoring (CGM). CGM is best placed as an adjunct to routine intermittent blood glucose monitoring, providing information on glucose trends d...

Cochrane Database Syst Rev. 2021 Dec 21;12(12):CD013309. doi: 10.1002/14651858.CD013309.pub3. PMID: 34931697.Brief Summary: This systematic review assessed the evidence for continuous glucose monitoring (CGM) to prevent morbidity and mortality in preterm infants. There was uncertainty about the safety of CGM and the available management algorithms, and many morbidities remain unreporte...

To read the full abstract: Diabetes Care. 2020 Apr;43(4):906–908. doi: 10.2337/dc19-2126. Epub 2020 Jan 23. PMID: 31974101Antenatal corticosteroid administration prior to planned cesarean section in early labour reduces by >50% the risk of admission to the neonatal intensive care unit for respiratory distress syndrome and transient tachypnea of the newborn. However, among pregnant women wit...

To read the full abstract: Lancet Child Adolesc Health 2020; 4: 23–35. doi: 10.1016/S2352-4642(19)30323-2• The study reports the worldwide prevalence of insufficient physical activity among school-going adolescents aged 11–17 years.• Data from surveys totalling 1.6 million students aged 11–17 years were analysed.• The majority of adolescents do not prese...

To read the full abstract: Hum Genet. 2018; 137(11–12): 955–960.Patients with Congenital adrenal hyperplasia (CAH) suffer from multiple comorbidities, including mental illness. Studies that investigated the prevalence of psychiatric disorders in patients with CAH showed that any psychiatric diagnosis were more common in CAH subjects compared with population controls. In p...