ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Sci Rep. 2019 Apr 30; 9(1): 6691.In recent years, improved knowledge of the metabolic risks in childhood cancer survivors (CCS) has increasingly focused research on modifiable factors and preventive strategies (1–2). It is well known that therapeutic irradiation can cause detrimental changes in body composition, but it is still unknown whether the specific...

To read the full abstract: Cell. 2018; 175(3): 695–708This paper demonstrates for the first time the existence of extracellular vesicle (EV)-mediated signaling between cell types within the adipose tissue. The results of various experiments show a network of EV-mediated exchange of cellular material in adipose tissue. This newly discovered EV trafficking in adipose tissue...

Pediatr Diabetes. 2019;20:93–98. DOI: 10.1111/pedi.12801• The quality and availability of pediatric diabetes management varies from setting to setting depending on the available resources.• In this position paper, the authors propose a ‘levels of care’ concept with three tiers that stratifies the existing levels of care into minimal care, interm...

Lancet Glob Health 2018;6: e875–84. DOI: 10.1016/S2214-109X(18)30231-6• Perinatal chronic undernutrition plays a role in adult-onset cardiometabolic disease.• In this 40-year, longitudinal cohort in Guatemala, protein-energy nutritional supplementation during the first 2 years of life reduced the odds of diabetes but increased the risk of obesi...

To read the full abstract: JAMA Pediatr 2019; 173(5):493–494.This double-blind, randomized controlled trial, in 345 US women who smoked cigarettes during pregnancy, showed that high (4 mg/day) versus standard dose (0.8 mg/day) folic acid increased mean birth weight by 140 grams, had a 31% lower risk of having a SGA baby, and a 35% lower risk of fetal growt...

To read the full abstract: Elife 2018;7. pii: e33318Here, Cheung et al. use sophisticated tissue specific genetic ablation in pituitary cell lineages to uncover an unexpected differential sensitivity of NOTCH activation signalling pathway in different cell lineages during the embryonic murine pituitary development. These findings are important as they further demonstrate the importance of NOTCH pat...

To read the full abstract: J Adolesc Young Adult Oncol. 2017;6:294-298The difficulties in defining obesity in childhood cancer survivors have been emphasised. In these patients, body mass index (BMI) has been confirmed to be a poor predictor of body fatness, because of their impaired linear growth, body composition changes (decreased lean mass and fat redistribution) and abdominal adiposity. Th...

To read the full abstract: Dig Dis Sci. 2017;62:3110-3116This retrospective single-centre study is the first to report the impact of anti-tumor necrosis factor (anti-TNF) therapy on weight gain in children with inflammatory bowel disease (IBD). The results are consistent with data in adults, in whom weight gain during anti-TNF treatment was negatively correlated to pre-treatment BMI (1). A si...

To read the full abstract: Journal of Pediatrics 2018;192:105-114Rising degree of obesity has been shown to predict increased metabolic risk in obese children and adolescents (1). Nonetheless, it is unclear if BMI categories can be successfully applied to populations of obese children and adolescents for a risk-adapted stratification of therapeutic approaches, and here especially for the in...

To read the full abstract: Lancet 2018; 391(10133):1953-1964[Comment on 13.5, 13.6 & 13.7] Published just a week before the World Health Organization put out their first Essential Diagnostics List (http://www.who.int/medical_devices/diagnostics/WHO_EDL_2018.pdf), this series of 3 papers highlights the previo...