ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: J Clin Endocrinol Metab. 2018 Aug 1; 103(8):2785GH deficiency (GHD) is common among children treated for cancer, especially among childhood cancer survivors (CCS) with tumors/surgery in the hypothalamic-pituitary (HP) region, CCS exposed to HP radiation or CCS exposed to cranial (CIR), craniospinal (CSI), or total body irradiation (TBI). However, most of existi...

Pediatr Diabetes. 2018 Apr 25. doi: 10.1111/pedi.12687. [Epub ahead of print]Transition of patients with chronic diseases from pediatric to adult care has become recognized as an important part of health care provision and its multifaceted challenges are increasingly being studied. This transition period is associated with deterioration of metabolic control and general health in young adults wi...

To read the full abstract: Diabetes Care. 2019;42:1297–1304In normal populations, high BMI is associated with higher mortality and morbidity, in particular from cardiovascular disease (CVD). In contrast, in type 1 diabetes (T1D), low body weight has been associated with increased mortality risks. This study investigated the importance of weight and weight gain/loss in patients with ...

Cell. 2018; 175(2): 514–29 e20.URL: http://www.ncbi.nlm.nih.gov/pubmed/30220461Summary: The enigma of how cholesterol is transported within cells has been solved in these experimental mouse models and structural imaging studies by the discovery of the proteins Aster A, B and C, which serve as a molecular bridge for the transfer of cholesterol from the pl...

To read the full abstract: Dev Cell. 2018 Nov 5;47(3):294–305.e7.Steroid hormones were believed to enter target cells via passive diffusion through the plasma membrane. This article shows that, at least for Drosophila, steroid hormones require a protein transporter to enter cells.Genomic functions of steroid hormones are mediated by intracellular nuclear recep...

To read the full abstract: JAMA Pediatr 2019;173:160–168This paper describes a large population-based cohort of women in New Zealand who received metformin (n=1996 women) or insulin (n=1932) for treatment of gestational diabetes mellitus (GDM). There were no differences between the two groups in any measure of offspring childhood hei...

To read the full abstract: JAMA Pediatr 2018;172:e180739.This randomised controlled trial of 1303 exclusively breastfed 3-month-old UK infants was primarily performed to test the impact of early introduction of solid foods, from age 3 months, on the risk of food allergies (1). Sleep was measured as a secondary trial outcome: the trial showed that early introduction of solids increa...

To read the full abstract: JAMA Pediatr 2018;172:1153–1160.This paper describes a gene-environment interaction twin study in 925 UK families (1850 twins). The heritability of childhood BMI was calculated by comparing the concordance in BMI at mean age 4.1 years between monozygous and dizygous twins; heritability was much higher among more obesogenic households (h2=8...

To read the full abstract: Nat Med. 2019 Mar;25(3):439–447.Prenatal screening for trisomy 21, trisomy 18, trisomy 13, and sex chromosome aneuploidies can be performed using next-generation sequencing of cell-free DNA (cfDNA) in the maternal circulation. This article describes a new non-invasive prenatal screening (NIPS) approach for the detection of de novo or paternally inheri...

To read the full abstract: Development 2018;145. pii:dev146829Branching morphogenesis is a key process during organogenesis of ductal and exocrine organs, e.g. lung, kidney, pancreas, and liver1. Regulatory components and local interactions for lung branching morphogenesis have been described in detail, mostly relying on receptor-ligand interactions between embryonic ...