ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: J Pediatr Endocrinol Metab. 2018 Jul 26;31(7):701–710.This meta-analysis assesses the prevalence of intracranial lesions in girls with central precocious puberty and hence evaluates the benefit of routine MRIs in girls with puberty onset at age 6–8 years.Central precocious puberty (CPP) is defined as the developme...

To read the full abstract: J Matern Fetal Neonatal Med. 2017 Oct 16:1-8Gestational diabetes mellitus (GDM) is one of the common metabolic diseases during pregnancy, affecting ~14% of all pregnancies. Better recognition of the risk factors of GDM, combined with more universal screening for the disease in many countries, has led to the increased detection of GDM along with other forms of pr...

To read the full abstract: Nat Commun 2017;8:443G-protein-coupled receptors (GPCRs) are a large family of receptors localized at the cell membrane, detecting specific ligands such as hormones, neurotransmitters, odors, pheromones. Further, GCPRs are the main element for the photoisomerization process, necessary to convert a photon impulse to an electrical signal in photosensitive gan...

To read the full abstract: Science Advances 2018;4:eaao5961Present-day humans have globular brains and globular endocasts with steep frontal, bulging parietal, and enlarged, rounded cerebellar areas with small and retracted faces. In contrast, Neandertals and other archaic Homo individuals have anterior-posteriorly elongated flat endocasts. These differences are well-visualized...

In Brief: Osteogenesis imperfecta (OI) is a genetically and phenotypically heterogeneous disorder which leads to significantly reduced quality of life (QoL) and high morbidity primarily due to frequent fractures, musculoskeletal pain, reduced mobility and loss of ambulation. This meta-analysis shows that QoL is significantly lower in children and adults with OI compared to normative data and controls.Commentary: Quality of life (QoL) is a multidimensiona...

Brief summary: This comprehensive narrative review provides a “Seminar” on congenital adrenal hyperplasia (CAH). The authors performed a thorough comprehensive qualitative summary of articles published mainly in Cochrane Library, MEDLINE, and Embase in English between Jan 1, 2005, and June 30, 2021, while not excluding commonly referenced and highly regarded older publications.Congenital adrenal hyperplasia (CAH) is an ‘umbrella’ clin...

Brief summary: This longitudinal study aimed to determine if hyperinsulinemia and postprandial glucose levels could predict obesity progression in n=591 children and adolescents with obesity. The authors found no association between hyperinsulinemia, insulin secretion, low postprandial glucose levels, and an increase in obesity over a 2–4-year period.According to the carbohydrate-insulin model (1), diets with a high glycemic load (GL) promote weight...

christine.martinez-vinson@aphp.fr J Pediatr Gastroenterol Nutr. 2021; 73: 231-235. PMID: 33908740.Brief Summary: This retrospective study evaluated longitudinal changes in bone mineral density (BMD) in children and adolescents with Crohn disease (CD), and the risk factors for low BMD. Low BMD (defined as BMD Z score ≤ -2.0) was present in 18.7% of patients at diagnosis and in 16% at ...

sumudu@pdt.cmb.ac.lk BMC Pediatrics 2021 21:262. doi: 10.1186/s12887-021-02742-9Brief Summary: This questionnaire-based case control study showed that girls with classical congenital adrenal hyperplasia (CAH) had more masculinized gender-role behaviour (GRB) and a tendency for ambiguous gender-identity (GI) compared to healthy children. The most li...

To read the full abstract: Int J Mol Sci. 2019 May 27;20(10). pii: E2590. doi: 10.3390/ijms20102590. PMID:31137773.Ion channels and transporters play essential roles in excitable cells, including cardiac, skeletal and smooth muscle cells, neurons, and endocrine cells. In pancreatic beta-cells, KATPchannels link the metabolic signals generated inside the cell to changes in the beta-cell membra...