ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

Page 7 of about 186 results

ey0018.5-13 | Advances in skeletal biology | ESPEYB18

5.13. SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation

A Haseeb , KC Ranjan , M Angelozzij , C de Charleroy , D Rux , RJ Tower , L Yao , R Pellegrino da Silva , M Pacifici , L Qin , V Lefebvre

Proc Natl Acad Sci USA 2021 Feb 23;118(8):e2019152118. Abstract: https://pubmed.ncbi.nlm.nih.gov/33597301/In brief: Sox9 is the key transcription factor and master regulator of chondrocyte differentiation during skeletal development. This paper demonstrates that SOX9 also has a key role during postnatal life to maintain open growth plates and healthy articular cartilage by preventi...
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ey0018.12-14 | Lipids | ESPEYB18

12.14. Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a mendelian randomization analysis using outcomes in first-degree relatives

Richardson Tom G , Wang Qin , Sanderson Eleanor , Mahajan Anubha , McCarthy Mark I , Frayling Timothy M , Ala-Korpela Mika , Sniderman Allan , Smith George Davey , Holmes Michael V

Lancet Healthy Longevity 2021 10.1016/S2666-7568(21)00086-6.In brief: Using a multivariable Mendelian randomization approach, genetic data on lipoprotein lipid levels and disease outcomes indicated that higher Apolipoprotein B (ApoB) levels increase the risks of coronary heart disease, stroke and T2DM, and shorten longevity. ApoB is emerging as a more sensitive measure of disease r...
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ey0018.13-7 | Endocrinology | ESPEYB18

13.7. We all have a role to play: redressing inequities for children living with CAH and other chronic health conditions of childhood in resource-poor settings

K Armstrong , AB Yap , S Chan-Cua , ME Craig , C Cole , V Chi Dung , J Hansen , M Ibrahim , H Nadeem , A Pulungan , J Raza , A Utari , P. Ward

Int. J. Neonatal Screen 2020; 6: 76. doi: 10.3390/ijns6040076– CLAN (Caring and Living as Neighbours) is an Australian non-governmental organisation (NGO) committed to a rights-based approach to optimizing quality of life for children and young people living with CAH and other chronic health conditions in resource-limited settings– This paper used exploratory case study as a method t...
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ey0018.15-3 | (1) | ESPEYB18

15.3. Metabolic effects of late dinner in healthy volunteers - a randomized crossover clinical trial

Gu Chenjuan , Brereton Nga , Schweitzer Amy , Cotter Matthew , Duan Daisy , Borsheim Elisabet , Wolfe Robert R , Pham Luu V , Polotsky Vsevolod Y , Jun Jonathan C

Journal of Clinical Endocrinology & Metabolism, 2020. Vol 105(8), 2789–2802. doi: https://doi.org/10.1210/clinem/dgaa354The authors performed a randomized crossover trial of Late Dinner (22:00 hours) vs Routine Dinner (18:00) in a laboratory setting in 20 healthy adult volunteers. Meal contents and sleep period (23:00-07:00) were kept the same in both arms and sleep patterns were u...
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ey0019.7-13 | Basic Science | ESPEYB19

7.13. Multi- and transgenerational outcomes of an exposure to a mixture of endocrine-disrupting chemicals (EDCs) on puberty and maternal behavior in the female rat

D Lopez-Rodriguez , CF Aylwin , V Delli , E Sevrin , M Campanile , M Martin , D Franssen , A Gerard , S Blacher , E Tirelli , A Noel , A Lomniczi , AS Parent

Environ Health Perspect.2021 Aug;129(8):87003. doi: 10.1289/EHP8795. Epub 2021 Aug 12. PMID: 34383603. https://ehp.niehs.nih.gov/doi/10.1289/EHP8795?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedBrief Summary: Using a rode...
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ey0019.8-2 | New Mechanisms | ESPEYB19

8.2. Corticosterone induces discrete epigenetic signatures in the dorsal and ventral hippocampus that depend upon sex and genotype: focus on methylated NR3C1 gene

SG Caradonna , NR Einhorn , V Saudagar , H Khalil , GH Petty , A Lihagen , C LeFloch , FS Lee , H Akil , A Guidotti , BS McEwen , E Gatta , J Marrocco

Transl Psychiatry. 2022; 12(1): 109. PMID: 35296634 https://pubmed.ncbi.nlm.nih.gov/35296634/Brief Summary: This mouse study identified sex and genotype-dependent effects of oral corticosterone on behavioral and physiological outcomes as well as on gene expression and epigenetics in hippocampal subregions.Glucocorticoids exert their effects by binding to glucocorticoid...
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ey0019.9-13 | Fertility issues and reproductive outcomes in childhood cancer survivors | ESPEYB19

9.13. Serum anti-Mullerian hormone as a marker of ovarian reserve after cancer treatment and/or hematopoietic stem cell transplantation in childhood: proposal for a systematic approach to gonadal assessment

S Molinari , F Parissone , V Evasi , Lorenzo P De , MG Valsecchi , S Cesaro , D Fraschini , R Sangalli , G Cacace , A Biondi , A Balduzzi , A Cattoni

s.molinari3@campus.unimib.it Eur J Endocrinol. 2021; 185: 717-728. PMID: 34519276.Brief Summary: This retrospective study, involving two Italian centers, enrolled post-pubertal female patients who had been treated with gonadotoxic therapies for hematological malignancies and/or hematopoietic stem cell transplantation (HSCT) before the age of 18 years. Several studies have r...
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ey0019.10-6 | New paradigms | ESPEYB19

10.6. Progression of type 1 diabetes from latency to symptomatic disease is predicted by distinct autoimmune trajectories

BC Kwon , V Anand , P Achenbach , JL Dunne , W Hagopian , J Hu , E Koski , AE Lernmark , M Lundgren , K Ng , J Toppari , R Veijola , BI Frohnert

T1DI Study Group. Nat Commun. 2022 Mar 21;13(1):1514. https://pubmed.ncbi.nlm.nih.gov/35314671/Brief Summary: This study of 5 birth cohorts of individuals at high risk for type 1 diabetes (T1D) used machine learning methods to explore trajectories from autoantibodies appearance to T1D progression. They identified 11 distinct latent health states and individuals progressed according to one o...
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ey0019.10-17 | New treatments | ESPEYB19

10.17. Efficacy of glucagon-like peptide-1 and estrogen dual agonist in pancreatic islets protection and preclinical models of insulin-deficient diabetes

T Fuselier , de Sa P Mota , MMF Qadir , B Xu , C Allard , MM Meyers , JP Tiano , BS Yang , V Gelfanov , SH Lindsey , RD Dimarchi , F Mauvais-Jarvis

Cell Rep Med 2022;3:100598. https://pubmed.ncbi.nlm.nih.gov/35492248/Brief Summary: This study used a combination of mice models and cultured human islets to show that a glucagon-like peptide-1 (GLP-1) and estrogen (E2) dual agonist (GLP1-E2) provides superior protection from insulin-deficient diabetes compared to GLP-1 and E2 monoagonists. Pancreatic islet protection...
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ey0019.11-7 | New findings in adipose tissue biology | ESPEYB19

11.7. Leptin resistance before and after obesity: evidence that tissue glucose uptake underlies adipocyte enlargement and liver steatosis/steatohepatitis in Zucker rats from early-life stages

MA Guzzardi , L Guiducci , D Campani , F La Rosa , A Cacciato Insilla , A Bartoli , M Cabiati , V De Sena , S Del Ry , S Burchielli , F Bonino , P Iozzo

patricia.iozzo@ifc.cnr.it Int J Obes (Lond) 2022, 46(1):50–58. doi: 10.1038/s41366-021-00941-zBrief Summary: This experimental study was conducted with fa/fa rats that have a homozygous defect in the leptin receptor and therefore severe leptin resistance. The animals develop extreme obesity, diabetes and metabolic syndrome. The study of y...
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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