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ey0016.12-11 | Lipid Metabolism | ESPEYB16

12.11. Aster proteins facilitate nonvesicular plasma membrane to ER cholesterol transport in mammalian cells

J Sandhu , S Li , L Fairall , SG Pfisterer , JE Gurnett , X et al. Xiao

Cell. 2018; 175(2): 51429 e20.URL: http://www.ncbi.nlm.nih.gov/pubmed/30220461Summary: The enigma of how cholesterol is transported within cells has been solved in these experimental mouse models and structural imaging studies by the discovery of the proteins Aster A, B and C, which serve as a molecular bridge for the transfer of cholesterol from the pl...

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ey0017.14-4 | (1) | ESPEYB17

14.4. Insights into human genetic variation and population history from 929 diverse genomes

A Bergstrom , SA McCarthy , R Hui , MA Almarri , Q Ayub , P Danecek , Y Chen , S Felkel , P Hallast , J Kamm , H Blanche , JF Deleuze , H Cann , S Mallick , D Reich , MS Sandhu , P Skoglund , A Scally , Y Xue , R Durbin , C Tyler-Smith

To read the full abstract: Science 2020; 367(6484):eaay5012.These authors sequenced 929 whole-genome sequences from 54 geographically, linguistically, and culturally diverse human populations, as part of the Human Genome Diversity Project, a panel of global populations. The data represent African, Oceanian, and American-Indian populations. They identified 67.3 million single-nucleotide polymorphisms (SNPs), 8.8 million small insertions or deleti...

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ESPE Yearbook of Paediatric Endocrinology

12.11. Aster proteins facilitate nonvesicular plasma membrane to ER cholesterol transport in mammalian cells

14.4. Insights into human genetic variation and population history from 929 diverse genomes

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