ESPE Yearbook of Paediatric Endocrinology

LGBT Health. 2022 May-Jun;9(4):238-246. PMID:35475663, doi: 10.1089/lgbt.2020.0494. Brief Summary: This study reports changes in wellbeing and quality of life in 70 adolescents (49 transgender men and 21 transgender women) from the Amsterdam Center for Expertise on Gender Dysphoria. It finds evidence of improvements in functioning on GAH. The purpose of gender-affirming ...

To read the full abstract: Cereb Cortex. 2020; 30(5): 2777–2788. PMID: 31819952.Congenital adrenal hyperplasia (CAH), most commonly caused by 21-hydroxylase deficiency, is an autosomal recessively inherited life-threatening impairment in cortisol and, in the severe salt wasting form, aldosterone synthesis. The implementation of neonatal screening programs for CAH and the continuous imp...

To read the full abstract: Stem Cell Res Ther. 2019 Oct 22;10(1):310. ellen.goossens@vub.beInfertility due to spermatogonial stem cell (SSC) loss is one of the major late adverse effects related to both chemotherapy and radiotherapy, and several researchers are now focusing on the development of new techniques to preserve germ cells.Semen sample storage is not feasible in prepuber...

Arch Sex Behav. 2018 Nov;47(8):2307–2317.doi: 10.1007/s10508-018-1218-3. PubMed ID: 29736809An increased incidence of autism spectrum disorder (ASD) among adolescents and adults with gender dysphoria has been reported in many studies. This paper describes one of the rare studies taking an opposite approach, by investigating the self-reported wish to be of the ...

To read the full abstract: JAMA Pediatr 2018;172:1153–1160.This paper describes a gene-environment interaction twin study in 925 UK families (1850 twins). The heritability of childhood BMI was calculated by comparing the concordance in BMI at mean age 4.1 years between monozygous and dizygous twins; heritability was much higher among more obesogenic households (h2=8...

To read the full abstract: Lancet Diabetes Endocrinol 2017;5:975-985Whereas most SGA children experience spontaneous catch-up growth leading to the achievement of normal adult height, approximately 10% remain short and are candidates for GH therapy. SGA subjects have increased cardio-metabolic disease risk [17] and the effects of GH treatment on blood...

To read the full abstract: J Clin Endocrinol Metab. 2017 Jul ;102 (7):2356-2363[Comments on 6.6, 6.7 and 6.8] These 3 papers deal with endocine pharmacological treatment of patients with GD.The first article by Chew et al. (6.6), from Australia, systematically reviews different pharmacolo...

To read the full abstract: Cochrane Database Syst Rev. 2017; 11:CD008727Glucocorticoids (GCs), such as prednisone (prednisolone) or dexamethasone, are essential agents in the treatment of acute lymphoblastic leukemia (ALL), the most common malignancy in childhood. They are administered in highly supraphysiologic doses in cyclic courses. Thus, every pediatric endocrinologist fears HPA axi...

Brief summary: In this longitudinal study, the authors investigated the metabolic and cardiovascular health profile of 167 adults born SGA and previously treated with rhGH during a period of 12 years after therapy discontinuation. No relevant differences were found in treated SGA subjects compared with untreated SGA adults or adults born appropriate for gestational age (AGA), thus suggesting long-term metabolic and cardiovascular safety of rhGH treatment in short SGA children....

Brief summary: This paper investigated the effect of pubertal suppression with GnRHa and gender affirming treatment with testosterone on the growth and final height of transgender boys. They found no negative effects, and even possibly a slight boost to adult height in comparison with target and predicted heights for birth-registered sex.One of the concerning features of transgender males is being able to identify with their cisgender peers in stature. I...