Aetiology and heterogeneity of type 1 diabetes

ey0015.10-1 | Aetiology and heterogeneity of type 1 diabetes | ESPEYB15

10.1 TCF7L2 genetic variants contribute to phenotypic heterogeneity of T1DM

MJ Redondo , S Geyer , AK Steck , J Sosenko , M Anderson , P Antinozzi , A Michels , J Wentworth , P Xu , A Pugliese , T1DM TrialNet Study Group

To read the full abstract: Diabetes Care. 2018;41:311-317Some researchers assume that the etiology of T1DM is distinct from that of Type 2 diabetes mellitus. T1DM is characterized by autoimmune phenomena leading to the destruction of pancreatic islets and most importantly of beta-cells. Genetic factors are thought to influence the likelihood of autoimmune phenomena developing into overt autoimmune di...

0 shares

ey0015.10-2 | Aetiology and heterogeneity of type 1 diabetes | ESPEYB15

10.2 Higher parental occupational social contact is associated with a reduced risk of incident pediatric T1DM: mediation through molecular enteroviral indices

AL Ponsonby , A Pezic , FJ Cameron , C Rodda , AS Kemp , JB Carlin , H Hyoty , A Sioofy-Khojine , T Dwyer , JA Ellis , ME Craig

To read the full abstract: PLoS One. 2018;13:e0193992Enterovirus infections in children are associated with an almost 10-fold higher risk of T1DM. In these families in parents and siblings enterovirus can frequently be detected by PCR. However, the role of enteroviral infections in the pathogenesis of T1DM is complex. Although enterovirus infections are less prevalent T1DM incidence increa...

0 shares

ey0015.10-3 | Aetiology and heterogeneity of type 1 diabetes | ESPEYB15

10.3 Frequency and phenotype of T1DM in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank

NJ Thomas , SE Jones , MN Weedon , BM Shields , RA Oram , AT Hattersley

To read the full abstract: Lancet Diabetes Endocrinol. 2018;6:122-129T1DM formerly called juvenile or insulin dependent diabetes has so far been considered to be a disease of children adolescents and young adults according to traditional teaching. LADA or late autoimmune diabetes of the adult is known since several decades, however the older the patient with new onset diabetes the more li...

0 shares

ESPE Yearbook of Paediatric Endocrinology

Yearbook of Paediatric Endocrinology 2018

10 Type 1 Diabetes Mellitus

10.1 TCF7L2 genetic variants contribute to phenotypic heterogeneity of T1DM

10.2 Higher parental occupational social contact is associated with a reduced risk of incident pediatric T1DM: mediation through molecular enteroviral indices

10.3 Frequency and phenotype of T1DM in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank

BiosciAbstracts