ISSN 1662-4009 (online)

Volume 15 | ESPEYB15 | Next issue

Yearbook of Paediatric Endocrinology 2018

4 Growth and Growth Factors

New perspectives

ey0015.4-9 | New perspectives | ESPEYB15

4.9 Childhood stature and growth in relation to first ischemic stroke or intracerebral hemorrhage

LK Gjærde , TC Truelsen , JL Baker

To read the full abstract: Stroke 2018;49:579-585Height is regulated by interplay of several factors, including genetic background, intra- and extra-uterine environment, nutrition, and others. Adult height has been inversely related with stroke risk [34] and coronary artery disease [35]...

ey0015.4-10 | New perspectives | ESPEYB15

4.10 Genetic screening confirms heterozygous mutations in ACAN as a major cause of idiopathic short stature

NN Hauer , H Sticht , S Boppudi , C Büttner , C Kraus , U Trautmann , M Zenker , C Zweier , A Wiesener , RA Jamra , D Wieczorek , J Kelkel , AM Jung , S Uebe , AB Ekici , T Rohrer , A Reis , HG Dörr , CT. Thiel

To read the full abstract: Sci Rep 2017; 22(7):12225The GH/IGF1 axis has historically been considered the most relevant regulator of growth. However, defects in the GH/IGF1 axis can be identified only in a minority of children with short stature. Human growth is dependent on chondrocyte proliferation and hypertrophy as well as structure and function of extracellular matrix in the gro...

ey0015.4-11 | New perspectives | ESPEYB15

4.11 Genetic analyses in small-for-gestational-age newborns

SE Stalman , N Solanky , M Ishida , C Alemán-Charlet , S Abu-Amero , M Alders , L Alvizi , W Baird , C Demetriou , P Henneman , C James , LC Knegt , LJ Leon , MMAM Mannens , AN Mul , NA Nibbering , E Peskett , FI Rezwan , C Ris-Stalpers , JAM van der Post , GA Kamp , FB Plötz , JM Wit , P Stanier , GE Moore , RC Hennekam

To read the full abstract: J Clin Endocrinol Metab 2018; 103:917-925SGA is often defined as a birth weight and/or length < −2 SDS for gestational age and gender [43]. A frequent cause of SGA is fetal growth restriction (FGR), often associated with perinatal mortality and morbidity and also implicated in a higher risk of cardio-metabolic disease in adulthood. ...