ESPE Yearbook of Paediatric Endocrinology

This year was significant for several articles that shed light on the genetics of type 2 diabetes (T2DM) in children. Rapidly emerging genomics tools enable study of large cohorts, identifying the genetic predisposition to obesity and T2DM, and understanding mechanisms of how these genes impact insulin secretion and resistance. Even in the genomic era, it is not genes alone, but the interplay of genetic and environmental factors that determines phenotype. The importance of rem...