New Mechanism (1)

ey0015.12-8 | New Mechanism (1) | ESPEYB15

12.8 Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

CA Thaiss , M Levy , I Grosheva , D Zheng , E Soffer , E Blacher , S Braverman , AC Tengeler , O Barak , M Elazar , R Ben-Zeev , D Lehavi-Regev , MN Katz , M Pevsner-Fischer , A Gertler , Z Halpern , A Harmelin , S Aamar , P Serradas , A Grosfeld , H Shapiro , B Geiger , E Elinav

To read the full abstract: Science 2018;359:1376-1383The metabolic syndrome (MetS) is associated with dysfunctions of the intestinal barrier, leading to increased permeability and translocation of microbial molecules into the intestinal lamina propria and to circulation. The entry of pathogens through an impaired barrier leads to an increased risk of infection, as well as to chronic inflammation...

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ESPE Yearbook of Paediatric Endocrinology

Yearbook of Paediatric Endocrinology 2018

12 Type 2 Diabetes, Metabolic Syndrome and Lipid Metabolism

12.8 Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

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