New mechanisms: food aversion

ey0015.15-8 | New mechanisms: food aversion | ESPEYB15

15.8 Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

JY Hsu , S Crawley , M Chen , DA Ayupova , DA Lindhout , J Higbee , A Kutach , W Joo , Z Gao , D Fu , C To , K Mondal , B Li , A Kekatpure , M Wang , T Laird , G Horner , J Chan , M McEntee , M Lopez , D Lakshminarasimhan , A White , SP Wang , J Yao , J Yie , H Matern , M Solloway , R Haldankar , T Parsons , J Tang , WD Shen , Y Alice Chen , H Tian , BB Allan

To read the full abstract: Nature 2017;550:255-259Loss of appetite, and even aversion to food, is a common experience during periods of illness (e.g. infection and pyrexia) and/or treatment (e.g. chemotherapy). This responses is distinct from the body’s homeostatic mechanisms (the hypothalamic leptin receptor-AGRP-POMC-MC4R axis), which normally regulate appetite and weight gain in ch...

0 shares

ESPE Yearbook of Paediatric Endocrinology

Yearbook of Paediatric Endocrinology 2018

15 Editor’s Choice

15.8 Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

BiosciAbstracts