ISSN 1662-4009 (online)

Volume 15 | ESPEYB15 | Next issue

Yearbook of Paediatric Endocrinology 2018

15 Editor’s Choice

The importance of being earnest about diurnal variation

ey0015.15-13 | The importance of being earnest about diurnal variation | ESPEYB15

15.13 A Transcriptional Circuit Filters Oscillating Circadian Hormonal Inputs to Regulate Fat Cell Differentiation

Z Bahrami-Nejad , ML Zhao , S Tholen , D Hunerdosse , KE Tkach , S van Schie , M Chung , MN Teruel

To read the full abstract: Cell Metabolism 2018;27:854-868. e8People gain weight due to treatment with glucocorticoid (GC) drugs, but also in chronic stress and disrupted circadian rhythms. We now learn that fat-cell maturation increases if the trough in exposure to GC lasts less than 12 hours. A long pulse of glucocorticoids lasting 48 hours led most of the cells to differentiate under the ...