ISSN 1662-4009 (online)

Volume 15 | ESPEYB15 | Next issue

Yearbook of Paediatric Endocrinology 2018

ey0015.1-8 | New mouse model | ESPEYB15

1.8 Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome

J Polex-Wolf , BY Lam , R Larder , J Tadross , D Rimmington , F Bosch , VJ Cenzano , E Cenzano , MK Ma , K Rainbow , AP Coll , S O'Rahilly , GS Yeo

To read the full abstract: J Clin Invest 2018;128:960-969Mouse models for PWS are urgently needed to facilitate drug development for treatment of hyperphagia and obesity in PWS patients. Here, the authors set out to create a mouse model that better recapitulates human PWS; they chose Snord116 as the target. Snord116 comprises a cluster of noncoding RNAs (ncRNAs) on paternal chromosome 15q11.2. Deletio...