Metabolic Signaling

ey0016.11-8 | Metabolic Signaling | ESPEYB16

11.8. An endothelial-to-adipocyte extracellular vesicle axis governed by metabolic state

C Crewe , N Joffin , JM Rutkowski , M Kim , F Zhang , DA Towler , R Gordillo , PE Scherer

To read the full abstract: Cell. 2018; 175(3): 695708This paper demonstrates for the first time the existence of extracellular vesicle (EV)-mediated signaling between cell types within the adipose tissue. The results of various experiments show a network of EV-mediated exchange of cellular material in adipose tissue. This newly discovered EV trafficking in adipose tissue...

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ey0016.11-9 | Metabolic Signaling | ESPEYB16

11.9. Exercise-induced changes in visceral adipose tissue mass are regulated by IL-6 signaling: A randomized controlled trial

AS Wedell-Neergaard , L Lang Lehrskov , RH Christensen , GE Legaard , E Dorph , MK Larsen , N Launbo , SR Fagerlind , SK Seide , S Nymand , M Ball , N Vinum , CN Dahl , M Henneberg , M Ried-Larsen , JD Nybing , R Christensen , JB Rosenmeier , K Karstoft , BK Pedersen , H Ellingsgaard , R Krogh-Madsen

To read the full abstract: Cell Metab 2019; 29(4): 84455This randomized, placebo-controlled, double blind trial showed that IL-6 is necessary for exercise-mediated loss of visceral adipose tissue mass. 53 participants (men and women) received either tocilizumab, an IL-6 signaling blocker (intervention group) or placebo (control group), every four weeks, in a ...

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ESPE Yearbook of Paediatric Endocrinology

Yearbook of Paediatric Endocrinology 2019

11 Obesity and Weight Regulation

11.8. An endothelial-to-adipocyte extracellular vesicle axis governed by metabolic state

11.9. Exercise-induced changes in visceral adipose tissue mass are regulated by IL-6 signaling: A randomized controlled trial

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