ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2019

4. Growth and Growth Factors

New Perspectives

ey0016.4-7 | New Perspectives | ESPEYB16

4.7. Idiopathic short stature and growth hormone sensitivity in prepubertal children

JGB Derraik , HL Miles , V Chiavaroli , PL Hofman , WS Cutfield

To read the full abstract: Clin Endocrinol. 2019;91:110–117.Idiopathic short stature (ISS) refers to a heterogeneous population of children with a height more than 2 SDS below the mean for age, sex, and population, in presence of normal birth size and body proportions, and without evidence of any identifiable cause. The use of next generation sequencing (NGS) has shown that a high p...

ey0016.4-8 | New Perspectives | ESPEYB16

4.8. Multigene sequencing analysis of children born small for gestational age with isolated short stature

BL Freire , TK Homma , MFA Funari , AM Lerario , GA Vasques , AC Malaquias , IJP Arnhold , AAL Jorge

To read the full abstract: J Clin Endocrinol Metab. 2019;104:2023–2030.A child born with birth weight and/or birth length less than 2 SDS below the mean for gestational age is defined as SGA [1]. This definition implies that rather than a specific diagnostic group, SGA children are a heterogenous population with different etiologies, growth patterns and metabolic outcomes. Most SGA ...

ey0016.4-9 | New Perspectives | ESPEYB16

4.9. Low IGF-I bioavailability impairs growth and glucose metabolism in a mouse model of human PAPPA2 p.Ala1033Val mutation

M Fujimoto , M Andrew , L Liao , D Zhang , G Yildirim , P Sluss , B Kalra , A Kumar , S Yakar , V Hwa , A Dauber

To read the full abstract: Endocrinology. 2019;160:1363–1376.Pregnancy-associated plasma protein A2 (PAPP-A2) is a metalloproteinase which, by cleaving IGFBP-3 and IGFBP-5, releases free IGF-I from the ternary complexes and regulates its bioavailability. PAPPA2 gene mutations (p.D643fs25* and p.Ala1033Val) have recently been described in various members of two unrelated fam...

ey0016.4-10 | New Perspectives | ESPEYB16

4.10. Associations of protein intake in early childhood with body composition, height, and insulin-like growth factor I in mid-childhood and early adolescence

KM Switkowski , PF Jacques , A Must , A Fleisch , E Oken

To read the full abstract: Am J Clin Nutr. 2019;109:1154–1163.Early life nutrition has long-term effects on body composition and obesity risk. Breastfed infants have a lower risk of obesity, which may be related to the lower protein intake in human milk compared to infant formula. Recent studies have confirmed the association between high-protein intake during the first years of lif...