ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2019

6. DSD and Gender Dysphoria

Food for Thought in Transgender Medicine

ey0016.6-13 | Food for Thought in Transgender Medicine | ESPEYB16

6.13. Parent reports of adolescents and young adults perceived to show signs of a rapid onset of gender dysphoria

L Littman

PLoS One. 2018 Aug 16;13(8):e0202330.doi: 10.1371/journal.pone.0202330. Erratum in: PLoS One. 2019 Mar 19;14(3):e0214157.A sharp and unexplained rise in the incidence of gender dysphoria has been observed worldwide among adolescents, especially natal girls. The causes and outcomes (in terms of persistence-desistence rates) of adolescent-onset gender dysphoria ar...

ey0016.6-14 | Food for Thought in Transgender Medicine | ESPEYB16

6.14 Genetic link between gender dysphoria and sex hormone signaling

M Foreman , L Hare , K York , K Balakrishnan , FJ Sanchez , F Harte , J Erasmus , E Vilain , VR Harley

J Clin Endocrinol Metab. 2019 Feb 1;104(2):390–396.doi: 10.1210/jc.2018-01105. PubMed PMID: 30247609.Polymorphisms in sex hormone genes have been described in gender dysphoric individuals with inconsistent findings. In this case-control study of 380 trans women and 344 control males, functional variants in 12 sex hormone signaling genes were studied. Significant a...