ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Elife 2019;8:e43999.Two populations of Kisspeptin neurons are described in the hypothalamus. One population is located in the rostral part of the hypothalamus (the anteroventral periventricular nucleus, AVPV); the other is in the arcuate nucleus (ARC). The major difference between these populations is the opposing effects of 17b-estradiol (E2) on Kiss1...

To read the full abstract: Endocrinology 2019;160:557–567.There is now no doubt that arcuate nucleus (ARC) kisspeptin neurons are the GnRH pulse generator. The authors analyzed the activity of ARC kisspeptin neurons by using a very powerful method based on the recording of calcium concentration within cells.ARC kisspeptin neurons activity was analyzed in male ...

To read the full abstract: Endocrinology 2019;160:1480–1491.There is now no doubt that arcuate nucleus (ARC) kisspeptin neurons are the GnRH pulse generator. (With paper 1.8) this second paper describes the activity of the GnRH pulse generator across the estrous cycle. In this work, the variable level of E2 represented an additional complexity. The second interest was to understand ...

To read the full abstract: Endocrinology 2019;160:1323–1332.Elevated prolactin levels suppress pulsatile release of GnRH from the hypothalamus, with a consequent reduction in pulsatile LH secretion from the pituitary. In this paper, the authors showed in mice that kisspeptin neurons located in the arcuate nucleus (ARC) respond to prolactin and conditional knockout of the prolactin r...